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EC number: 219-307-8 | CAS number: 2408-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Skin sensitization test for CAS no: 334-48-5
- Author:
- HSDB
- Year:
- 2 017
- Bibliographic source:
- TOXNET Toxicology Data Network, 2017
- Reference Type:
- secondary source
- Title:
- SIDS Dossier for CAS no: 96-05-9
- Author:
- OECD HPV Chemical Programme
- Year:
- 2 009
- Bibliographic source:
- OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 29, 20-23 October 2009
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin sensitization study of allyl methacrylate was performed by patch Test in guinea pig
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- No data available
Test material
- Reference substance name:
- Allyl methacrylate
- EC Number:
- 202-473-0
- EC Name:
- Allyl methacrylate
- Cas Number:
- 96-05-9
- Molecular formula:
- C7H10O2
- IUPAC Name:
- 2-methyl-2-propenoic acid 2-propenyl ester
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): allyl methacrylate
- Molecular formula: C7H10O2
- Molecular weight: 126.154g/mole
- Substance type: Organic
- Physical state: : liquid
Constituent 1
- Specific details on test material used for the study:
- Details on test material
- Name of test material (as cited in study report): allyl methacrylate
- Molecular formula: C7H10O2
- Molecular weight: 126.154g/mole
- Substance type: Organic
- Physical state: : No data available
- Purity: >98%
- Impurities (identity and concentrations): <2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Hartley albino
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100%
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 100%
- No. of animals per dose:
- Total :20
Treated group:10
Control group:10 - Details on study design:
- Details on study design
RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 4
- Exposure period: No data available
- Test groups:10
- Control group:10
- Site: No data available
- Frequency of applications: 4 times in 10days
- Duration: 10 days
- Concentrations: undiluted
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge: No data available
- Exposure period: No data available
- Test groups:10
- Control group:10
- Site: No data available
- Concentrations: undiluted
- Evaluation (hr after challenge): No data available - Challenge controls:
- yes
- Positive control substance(s):
- yes
- Remarks:
- dinitrochlorobenzene (DNCB).
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
- Positive control results:
- All the animals in positive control group were sensitized
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No skin sensitization reaction was observed
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The allyl methacrylate (96-05-9) was considered to be not sensitizing to guinea pig
- Executive summary:
The skin sensitizing study of allyl methacrylatewas carried out inHartleyalbino guinea pig by patch test method.10 animals in treated group and 10 animals in positive control group were observed.Dinitrochlorobenzene (DNCB) used as positive control. The repeated insult patch tests carried out either with test material or with dinitrochlorobenzene (DNCB) 4 times in 10 days.No skin reactions were observed in treated group while all the animals in positive control group were sensitized. Therefore, based on the results obtained, theallyl methacrylate(96-05-9)was considered to be non-sensitizing to skin of guinea pig.
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