Registration Dossier
Registration Dossier
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EC number: 200-699-4 | CAS number: 68-96-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- other: screening method (solvent: DMSO)
- Water solubility:
- 0.014 g/L
- Remarks on result:
- other: temperature range of 25 to 30°C
- Conclusions:
- The water solubility of Hydroxyprogesterone was 0.014 g/L at 20-30°C.
- Executive summary:
The water solubility of 0.014 g/L was determined in "pretest quality" using a screening method based on the detection of the beginning of precipitate formation upon portion-wise addition of an organic solution of the respective test substance under continuous stirring into an excess volume of water while maintaining a temperature range of 25 to 30 °C. Due to the specifics of the screening method, the above value is expected to represent an upper limit which should not be exceeded by the test substance in its crystalline form. The solubility lies well below the lower limit set by the VCI guidance of 0.1 g/l. Therefore no further measurements are necessary within the scope of this study.
Reference
Description of key information
The water solubility is 0.014 g/L measured between 25 and 30°C.
Key value for chemical safety assessment
- Water solubility:
- 0.014 g/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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