Registration Dossier
Registration Dossier
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EC number: 211-112-6 | CAS number: 629-82-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dioctyl ether
- EC Number:
- 211-112-6
- EC Name:
- Dioctyl ether
- Cas Number:
- 629-82-3
- Molecular formula:
- C16H34O
- IUPAC Name:
- 1-(octyloxy)octane
- Test material form:
- liquid
- Details on test material:
- - State of aggregation: Colorless, clear liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Cetiol OE
- Physical state: liquid
- Analytical purity: >99.9%
- Lot/batch No.: 7/91
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No mortality was observed.
- Mortality:
- no mortality
- Clinical signs:
- other: no effects
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50>2000 mg/kg body weight
- Executive summary:
The acute oral toxicity of the test substance was investigated in young adult Wistar rats according to OECD guideline 401. The test article was dissolved in arachidis oil and given orally by means of a stomach tube in a dose of 2000 mg/kg body weight to 5 male and 5 female animals. At frequent intervals at the day of application and twice a day in the following 14 days, the rats were observed for any signs of reaction. The surviving rats were sacrified at the end of the observation period and a macroscopic postmortem examination was performed on all rats. The LD50 was >2000 mg/kg for male and female rats.
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