Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-275-3 | CAS number: 1125503-33-4
Endpoint summary
Administrative data
Description of key information
In accordance with column 2 of Reach Regulation (EC) No 1907/2006, Annex VII the skin sensitization study (required in section 8.3) skin sensitization testing was not conducted in animals with HYEQS as the test substance is corrosive. However, HRIP-Testing was performed with preparations of HYEQS demonstrating no skin sensitization potential under known conditions of use.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitization potential of Alkyl dimethyl hydroxyethyl ammonium chloride was assessed in four independent HRIPT (human repeat insult patch) studies. The test item (in a detergent matrix or alternativ as aqueous solution (w/v)) was exposed
on patches to the skin of volunteers in preparation concentrations of at least 0.2 % (w/v) in water up to 0.5 % (w/v) in water. In total 9 inductions were performed. 14 days after final insult patch, treatment sites were challenged and observed 48 and 96 hours after patch. Mild erythema (grade 1) was determined in some of the subjects of the four studies during the challenge. In all four studies there was no evidence that the test item was a sensitizer under the test conditions.
Migrated from Short description of key information:
In accordance with column 2 of Reach Regulation (EC) No 1907/2006, Annex VII the skin sensitization study (required in section 8.3) skin sensitization testing was not conducted in animals with HYEQS as the test substance is corrosive. However, HRIP-Testing was performed with preparations of HYEQS demonstrating no skin sensitization potential under known conditions of use.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
Inhalation is no endpoint of concern since inhalation is no critical route of exposure and no peak exposures are to be expected. No animal study was performed.
Justification for classification or non-classification
HRIP-Testing was performed with preparations of Quaternary ammonium compounds, C12-14, even numbered, alkyl(hydroxyethyl) dimethyl, chlorides (HYEQS) demonstrating no skin sensitization potential under known conditions of use. Therefore, no classification is indicated. No classification for respiratory toxicity is deducible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
