4,8-Cyclododecadien-1-one

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11-03-2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

inspected: January 2013; signature: March 2013

Type of method:

differential scanning calorimetry

Boiling pt.:

>= 250 - <= 255 °C

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

> 180 °C

Remarks on result:

other: The measured boiling range is considered to be indicative of that of partially degraded test item; the decomposition reported is indicative of oxidation/rearrangement reactions occuring prior to boiling at > 180 °C.

Table 1. Results of the DSC analysis:

Run Number	Sample Weight / mg	Onset of effect / °C	Range of Effect / °C	Air Pressure / hPa	Remarks
1	12.94	-29.74	-35 – -29 (exo)	1016.4	Cooling run (- 0.25 K/min)
		-11.15	-15 – 0 (endo)	1016.4	Heating run (+10 K/min)
		186.05	180 – 230 (exo)
		249.79	230 – 310 (endo)
2	13.43	-33.36	-35 – -30 (exo)	1016.8	Cooling run (- 0.25 K/min)
		-11.15	-15 – 0 (endo)	1016.8	Heating run (+10 K/min)
		184.39	180 – 230 (exo)
		254.79	230 – 310 (endo)

 

The test item showed a small exothermic effect in the temperature range of 180 – 230 °C which was directly followed by an endothermic signal in the temperature range of 230 - 310°C that can be associated with the boiling of the test item. For the correction of the boiling temperature to standard pressure the test item was assigned to chemical group 2 (e.g.Hydrocarbons, Camphor). A correction value φ = 5.05 was used for the temperature range from 250°C to 260 °C. The lowest measured onset temperature is corrected to the normal pressure to be 249.65 °C and the highest onset temperature to be 254.63 °C. As the corrected onset temperatures in both tests deviate by more than 0.5 K from their mean value of 252.14 °C, the test item has a boiling range from 250 °C to 255 °C. No further thermal effects were observed up to the test end temperature of 500 °C

Measurements by the capillary method:

To verify the results of the DSC-measurement, an additional measurement with the capillary method was performed in the temperature range 180 – 300 °C with a heating rate of 10 K/min. The observations during the test with the capillary method is provided in table 2.

Table 2: Observations during the test with the capillary method (Heatingrate:10 K/min from 180 °C to 300 °C)

	Sample
Start (180°C)	Colourless liquid
205°C	Change in colour to yellowish
210°C	Bubble formation
280°C	Change in colour to brownish, test item is boiling out of the capillary
295°C	Capillary almost empty

 

The measurement with the capillary method within the temperature range of 180 °C to 300 °C confirmed the results of the DSC-measurements. The exothermic effect in the temperature range of 180 – 230 °C can be associated with a change in colour of the test item at about 205 °C. The endothermic signal in the temperature range of 230 – 310 °C was confirmed as the boiling range of the test item.

Conclusions:

The test item was observed to decompose at > 180 °C. The test item boiling temperature range was determined to be 250 °C to 255 °C at 1013.25 hPa atmospheric pressure.

Executive summary:

The boiling temperature was determined using OECD TG 103 and EU Method A.2: Differential Scanning Calorimetry (DSC) method. The test substance was tested in duplicate. The test item was observed to decompose at > 180 °C in duplicate and this was confirmed by further capillary method testing, observed colour changes. The test item boiling temperature range was determined to be 250 °C to 255 °C at 1013.25 hPa atmospheric pressure.

Description of key information

Decomposes at > 180 °C. Bp Range: 250 °C to 255 °C at 1013.25 hPa atmospheric pressure, OECD TG 103 - DSC method, 2014

Additional information

The boiling temperature was determined using OECD TG 103 and EU Method A.2: Differential Scanning Calorimetry (DSC) method. The test substance was tested in duplicate. The test item was observed to decompose at > 180 °C in duplicate and this was confirmed by further capillary method testing, observed colour changes. The test item boiling temperature range was determined to be 250 °C to 255 °C at 1013.25 hPa atmospheric pressure.