Registration Dossier
Registration Dossier
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EC number: 266-405-1 | CAS number: 66557-45-7
Endpoint summary
Administrative data
Description of key information
The target substance (brominated form) is not irritating to skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
For skin irritation testing, each animal was treated with 0.5 g Disperse Violet 93:1 pasted with water.
Examinations of the skin took place after 60 minutes as well as 24, 48 and 72 hours and 7/8 days after removal of the patches.
Erythema, eschar formation and oedema were evaluated numerically according to the score of DRAIZE. All other changes of the skin were recorded.
No signs of irritation occurred during the whole study.
Testing of Disperse Violet 93:1 for primary dermal irritation in the rabbit showed, that the substance is not irritating to skin.
100 µL (ca. 10 mg) Disperse Violet 93:1was applied once to the conjunctival sac of the left eye of three rabbits. The untreated eyes served in each case as a control.
The eyes were examined 1, 24, 48 and 72 hours and 7/8 days after application of the test substance.
At 24 hours the eyes were also examined for corneal lesions under UV light after instillation of one drop of a fluorescein solution. Lesions in cornea. iris or conjunctivae were graded numerically. All other changes or toxic effects were recorded.
Based on the individual scores after 24, 48 and 72 hours, no signs of irritation were noted
Testing of Disperse Violet 93:1 Br for primary eye irritation in the rabbit showed, that the substance is not irritating to the eye. The same is considered for the chlorinated target substance Disperse Violet 93.1 Cl.
Justification for classification or non-classification
No signs of irritation in skin or eye (in vivo).
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