Registration Dossier
Registration Dossier
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EC number: 203-778-1 | CAS number: 110-56-5
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Experimental toxicity test on aquatic organisms with 1,4-dichlorobutane are availbale for fish and algae as well as for microorganism. The key study of the acute fish test with Piemphales promelas (fathead minnow) resulted in an LC50 of 51.6 mg/L after 96 h of exposure. The study has been performed similar to guideline and is well documented. This result is supported by a test performed according to national guideline (DIN38412 part 15), which showed an LC50 of 83 mg/L for Leuciscus idus melanotus (orfe). Further, a QSAR model by Zvinavashe et al 2007 estimated an LC50 of 2.47 µmol/L (corresponding to 37.5 mg/L). Another publication reported a LC50 of 3.39 mM for Pimephales promelas (=51.6 mg/L), which is correspond to the key study.
A key study with green algae (Desmodesmus subspicatus) according to national guideline (38412 part 12) revealed an effect level EC50 of 132 mg/L after 24 h and an EC10 of 38 mg/L. An additional study cited an EC50 value of 390 mg/L with green algae. No experimental data with daphnia are available.
The toxicity on microorganisms has been examined in a key study according to national guideline DIN 38412 part 12 and revealed half of the respiration inhibited at concentrations of 181 mg/L (EC50) after 24 h and an EC10 of 56 mg/L. Furthermore, the toxicity on microorganisms has been determined in a bioluminescence inhibition bio assay with Shk1 and Vibrio fisheri. The tests determined values corresponding to an EC50 of 271 mg/L for Shk1 and an EC50 of 62.2 mg/L for Vibrio fisheri, supporting the results of the key study.
Conclusion on classification
The experimental result of the key study with fathead minnow showed a LC50 of 51.6 mg/L. This results is supported by further studies. No experimental data are available for daphnia. The EC50 value for green algae are above the relevant range for classification. As no reliable data on biodegradation is available, the test substance has to be considered as not readily biodegradable according to CLP regulation. Therefore, a classification of aquatic chronic, category 3 according to CLP regulation is appropriate, and aquatic acute category 3 according to UN-GHS .
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