2,6,8-trimethylnonan-4-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 March - 15 April 1949

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted prior to GLP and guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1949

Report date:

1949

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Undiluted test material was in contact with skin of rabbits for a 24 hour period. Following that, the animals were observed for 14 days A gross examination was performed on animals that died

GLP compliance:

no

Test type:

other: Range finding study

Test material

Test material information

Constituent 1

Reference substance name:

2,6,8-trimethylnonan-4-ol

EC Number:

204-606-8

EC Name:

2,6,8-trimethylnonan-4-ol

Cas Number:

123-17-1

Molecular formula:

C12H26O

IUPAC Name:

2,6,8-trimethylnonan-4-ol

Details on test material:

- Name of test material (as cited in study report): 2,6,8-Trimethyl Nonanol

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male

Details on test animals or test system and environmental conditions:

Weight of rabbits prior to dosing ranged from 1974 - 2854g.

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Test material was applied undiluted with the clipped skin of the rabbit trunk under impervious "Vinylite" sheeting for a period of 24 hours.

Duration of exposure:

24 hours.

Doses:

2.52, 5.0, 10 and 20 ml/kg

No. of animals per sex per dose:

5 male rabbits/dose level

Control animals:

not specified

Details on study design:

Animals had the test material applied to clipped skin for 24 hours under impervious "Vinylite" sheeting. The animals were observed for a 14 day observation period. Rabbits that died during the observation period were subjected to a gross necropsy.

Statistics:

The LD50 was calculated. Method not stated in report. However, the acute oral LD50 was determined using the method of Thompson.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

11.2 mL/kg bw

Based on:

test mat.

95% CL:

5.1 - 24.7

Mortality:

20 ml/kg
4 of 5 rats died. Two died on day 2, one on day 5 and one on day 9.

10 ml/kg
One of five died during the observation period. This animal died on day 4.

5.0 ml/kg
Two of 5 animals died during the 14 day observation period. One died on day 4 and the other died on day 7.

2.52 ml/kg
One of 5 rabbits died during the 14 day observation period. This animal died on day 8.

Clinical signs:

other: Erythema of varying intensity on the skin with subsequent desquamation and slight necrosis in one or two instances was noted.

Gross pathology:

The kidneys of the victums were often mottled and pale.

Other findings:

No additional information available.

Any other information on results incl. tables

The LD50 was 11.2 (5.1 - 24.7) ml/kg.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Based on the results of Skin penetration test conducted on rabbits, the range finding LD50 value was found to be 11.2 (5.1 to 24.7) ml/kg for the undiluted compound.

Executive summary:

The dermal toxicity of Trimethyl Nonanol was examined. Based on the results of this study conducted on rabbits, the range finding LD50 value was found to be 11.2 (5.1 to 24.7) ml/kg for the undiluted compound.