Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-231-8 | CAS number: 12136-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-04-17 to 1991-04-04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium molybdate
- EC Number:
- 231-551-7
- EC Name:
- Disodium molybdate
- Cas Number:
- 7631-95-0
- Molecular formula:
- MoO4.2Na
- IUPAC Name:
- Disodium tetraoxomolybdate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Sodium Molybdate
- Physical state: white crystalline powder
- Stability: stable
- Analytical purity: 99.9%
- Storage condition of test material: in the dark at room temperature
- Production date: 1990-04-12
- Other: prior to use in this study a subsample was sent to Microm Hills Ltd., Orpington, Kent where it was air-milled to the extent technically feasible
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Limited, Margate, Kent, UK
- Age at study initiation: 6 - 8 weeks
- Weight at study initiation: ca. 200g
- Housing: 5 per sex per cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 24 °C
- Humidity (%): 35 - 65%
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Wright dust generator
- Exposure chamber volume: 120 L
- Method of holding animals in test chamber: cages of stainless mesh partitioned to provide 10 individual animal compartments
- Source and rate of air: clean dried compressed air was connected to the dust generator and flow rate was 25 L/min
- Method of particle size determination: Two samples were taken using a Marple model 296 cascade impactor.
- Temperature, humidity, pressure in air chamber: the air temperature was measured and recorded at the start of the exposure and then at 30 min intervals during the 4-hour exposure, relative humidity was calculated from the recorded data for the water vapour content and temperature of the chamber air
TEST ATMOSPHERE
- Brief description of analytical method used: five air samples were taken from the chamber during the exposure. Each air sample was withdrawn through a weighed glass fibre filter (Whatman GF/A) held in an open face filter holder, at a rate of 4 L/min. The volume of the air sample was measured with a wet-type gas meter. The filters were reweighed to determine the concentration of the test substance in the chamber air. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- The mean concentration of Sodium molybdate was 1.93 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least two times per day for clinical signs
- Frequency of weighing: every day
- Necropsy of survivors performed: yes
- Food and water consumption: the daily mean intakes of food and water for each rat were calculated from the recorded data
- Other examinations performed:
at the end of the 14 day observation period, the rats were subjected to a detailed macroscopic examination. The lungs were removed, dissected clear of surrounding tissue and weighed in to order to calculate the lung to body weight ratio. Lungs, Liver and Kidneys were preserved buffered 10% formalin. Fixed lungs were embedded in paraffin wax and four-micron sections were prepared, stained with haematoxylin and eosin and examined under the light microscope. - Statistics:
- N.A.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1.93 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: During exposure: Partial closing of the eyes was seen in rats exposed to Sodium molybdate. This sign is considered to be consistent with a non-specific response to exposure to high concentration of dust. During the observation period: No signs of toxicity
- Body weight:
- Small losses in body weight or a reduced rate of body weight gain were observed in rats exposed to Sodium molybdate for up to three days after exposure. Subsequently the rate of body weight gain of the exposed rats was similar to that of the control rats.
- Gross pathology:
- Macroscopic pathology:
The lungs of two control rats had dark areas on the surface of the lungs and the lungs of one male rat exposed to Sodium molybdate were congested (animal 95).
Microscopic pathology:
No changes considered to be of toxicological significance were observed in the lung sections examined. - Other findings:
- Food consumption:
Food consumption was reduced for two days following exposure to Sodium molybdate. Subsequently, food consumption for exposed rats was similar to that for control rats.
Water consumption:
Water consumption was increased on Day 3 of the observation period and also, in male rats only, on day 4 after exposure.
Lung to body weight ratio:
The lung weight for one male rat (animal 95) exposed to Sodium molybdate was higher than normal. The ratio was considered to be within normal limits for all other rats.
Any other information on results incl. tables
Table 1: Concentrations of Sodium Molybdate | |||
Sample | Time | Test Item in air (mg/L) | |
2.1 | 0h : 30 min | 2.01 | |
2.2 | 1h : 00 min | 1.85 | |
2.3 | 2h : 00 min | 1.94 | |
2.4 | 3h : 00 min | 1.93 | |
2.5 | 3h : 50 min | 1.91 | |
mean | 1.93 |
Variation: 8%
Table 2: Particle Size Distribution | |||||||
Sample | Time taken | Stage | Particle size range (µm) | Amount collected (mg) | % of total | % respirable (< 3.5 µm a.d.) | |
PSD1 | 1h : 40 min | 3 | 9.80 | 0.37 | 42.50 | 31.00% | |
4 | 6.00 | 0.09 | 10.30 | ||||
5 | 3.50 | 0.14 | 16.10 | ||||
6 | 1.55 | 0.27 | 31.00 | ||||
7 | 0.93 | 0.00 | 0.00 | ||||
8 | 0.52 | 0.00 | 0.00 | ||||
Filter | 0.00 | 0.00 | 0.00 | ||||
PSD2 | 3h : 30 min | 3 | 9.80 | 0.34 | 30.60 | 20.70% | |
4 | 6.00 | 0.31 | 27.90 | ||||
5 | 3.50 | 0.23 | 20.70 | ||||
6 | 1.55 | 0.23 | 20.70 | ||||
7 | 0.93 | 0.00 | 0.00 | ||||
8 | 0.52 | 0.00 | 0.00 | ||||
Filter | 0.00 | 0.00 | 0.00 | ||||
mass median aerodynamic diameter: 6.9 µm; standard geometric diviation: 2.71 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, under the conditions of the test, the LC50 of Sodium molybdate is greater than 1.93 mg/L.
- Executive summary:
In an acute inhalation toxicity study equivalent to OECD 403, groups of young male and female Sprague-Dawley rats (5 per sex) were exposed via inhalation route to Sodium molybdate (99.7% purity) for 4 hours to the whole body at a mean concentration of 1.93 mg/L. Animals then were observed for 14 days. No mortality or distinct clinical signs were observed after exposure to Sodium molybdate. Since no mortality occured during the 14-day observation period, the LC50 for both sexes is greater than 1.93 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.