Registration Dossier
Registration Dossier
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EC number: 625-309-3 | CAS number: 6574-97-6
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE and Model
ECOSAR v1.11
2. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
N#Cc1cccc(c1Cl)Cl
3. APPLICABILITY DOMAIN
Molecule does not fit the exclusion criteria, so it is “in-domain”. Furthermore the predicted acute value for fish (25,4) is very close to the experimental one (24).
4. ADEQUACY OF THE RESULT
The predicted value of 15.6 mg/L together with the classification as non-readily biodegradable leads to a classification as “Chronic aquatic toxicity, Category 3, H412 Harmful to aquatic life with long lasting ef-fects.
Data source
Reference
- Reference Type:
- other: QSAR calculation
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
- Principles of method if other than guideline:
- see "justification for type of information"
Test material
- Reference substance name:
- 2,3-dichlorobenzonitrile
- EC Number:
- 625-309-3
- Cas Number:
- 6574-97-6
- Molecular formula:
- C7H3NCl2
- IUPAC Name:
- 2,3-dichlorobenzonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Water
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid: bulk
- Details on test material:
- This composition is the usual techical grade of AlzChem AG. It will be used when test substance has this composition (or is very closed) or no specific information is available.
Constituent 1
impurity 1
impurity 2
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 15.6 mg/L
Applicant's summary and conclusion
- Conclusions:
- Calculated EC50 of 2,3-Dichlorobenzonitrile is 15.6 mg/L after 48 h.
- Executive summary:
Calculated EC50 of 2,3-Dichlorobenzonitrile is 15.6 mg/L after 48 h
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