Registration Dossier
Registration Dossier
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EC number: 225-184-1 | CAS number: 4702-90-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used. A 50% aqueous preparation of the substance has been applied on the back and ear of rabbits for 20 hours, observations were reported after 24h, 48h, 5 days, 6 days 7 days and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- EC Number:
- 225-184-1
- EC Name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- Cas Number:
- 4702-90-3
- Molecular formula:
- C21H18N4O2
- IUPAC Name:
- 4,4'-methylylidenebis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)
- Details on test material:
- - Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male 2.76 kg, female 3.03 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 50% - Duration of treatment / exposure:
- 20 h
- Observation period:
- 24 h, 48 h, 5 d, 6 d, 7 d, 8 d
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back of animals
- Type of wrap if used: 2.5x2.5cm cotton lint moistened with test substance
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 20 h
SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- Yellow substance residues were reported.
Any other information on results incl. tables
Animal 1: male, 2.76 kg
Animal 2: female, 3.03 kg
Results:
| Readings | Animal | Erythema | Edema | Additional findings |
| 24 h | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 48 h | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 5d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 6 d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 7 d | 1 | 0 | 0 | s |
| 2 | 0 | 0 | s | |
| 8 d | 1 | 0.0 | 0.0 | s |
| 2 | 0.0 | 0.0 | s | |
| mean 24 - 72 h | 1 | 0.0 | 0.0 | |
| 2 | 0.0 | 0.0 | ||
| mean | 0 | 0 |
s: substance precipitation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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