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Diss Factsheets
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EC number: 282-104-8 | CAS number: 84100-23-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1981-07-14 to 1981-10-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-(1,1-dimethylethyl)cyclohexyl acrylate
- EC Number:
- 282-104-8
- EC Name:
- 4-(1,1-dimethylethyl)cyclohexyl acrylate
- Cas Number:
- 84100-23-2
- Molecular formula:
- C13H22O2
- IUPAC Name:
- 4-tert-butylcyclohexyl prop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River WIGA, Sulzfeld, FRG
- Age at study initiation: about 4 weeks
- Weight at study initiation: males: 22 - 28 g; females: 22 - 24 g
- Fasting period before study: The animals are given no feed for 16 hours before administration, but water is available ad libitum.
- Housing: 5 animals per cage (Makrolon cages, type I)
- Diet: ad libitum (SSNIFF R; Ssniff Versuchstierdiäten, Soest, FRG)
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 26
- Humidity (%): 45 - 75
- Photoperiod (hrs dark / hrs light): 12/12 (6.00 - 18.00 hours/ 18.00 - 6.00 hours)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Details on exposure:
- The test substance is insoluble in water.
Form of administration: emulsion
Concentrations used: 14, 20, 29.4 and 40 % (G/V)
Application volume: 5 mL/kg - Doses:
- 700, 1000, 1470 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: before administration, 2nd weighing 3 days, 3rd weighing 4 days, 4th weighing 7 days and 5th weighing 13 days after administration.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Cageside observation: Recording of signs and symptoms < 15 min, 15 min, 30 min, 1 h, 2 h, 4 h, and 5 h after administration of test substance and then once each workday. Check for moribund and dead animals twice each workday and once daily at weekends and on public holidays.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 1 470 mg/kg bw
- Mortality:
- Male animals: 700 and 1000 mg/kg: no deaths after 14 days; 1470 and 2000 mg/kg: 5/5 after 14 days
Female animals: 700 and 1000 mg/kg: no deaths after 14 days; 1470 and 2000 mg/kg: 4/5 after 14 days - Clinical signs:
- Male animals: Dyspnea, apathy, staggering, trembling, twitching, spastic gait, tonus with stretching, rolling convulsions, piloerection, exsiccosis, ptosis, disequilibrium, poor general state
Female animals: dyspnea, apathy, abnormal position, staggering, trembling, spastic gait, tonus with stretching, rolling convulsions, clonic convulsion, piloerection, exsiccosis, disequilibrium, paresis, ptosis, poor general state, cachexia - Body weight:
- Mean body weight male animals: 25.5 g at study start, 33.2 g after 13 days
Mean body weight female animals: 23.0 g at study start, 27.5 g after 13 days - Gross pathology:
- Animals that died: No intra abdominal precipitates of the test substance or adhesions.
Sacrificed animals: Organs: No abnormalities detected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.