Registration Dossier
Registration Dossier
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EC number: 483-300-8 | CAS number: 99580-93-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance (organic salt) is absorbed and distributed systemically when administered orally based on dose-related histopathological changes in the kidneys. No evidence for metabolism was found in in-vitro genetic toxicity tests (all negative w/wo metabolic activation). The high water solubility and small moleculare weights of the ions suggest that the substance should be systemically available via pulmonary absorption, but inhalation exposure depends on particle size. The low log Pow value and the ionic structure suggest that the substance will not bioaccumulate. Dermal absorption is considered to be very low based on results of dermal toxicity tests (LD50>2000 mg/kg, not irritant to skin (500 mg) nor to eye (100 mg); no sensitisation) indicating, that when applied dermally, the substance is not systemically toxic. The low log Pow value (-3.79 at 22°C) and the ionic structure suggest that the substance is not likely to be sufficiently lipophilic to cross the strateum corneum, therefore dermal absorption is likely to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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