Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Endpoint summary
Administrative data
Description of key information
Additional information
As aquatic toxicity studies for L-methionine were not available, studies performed with D,L-methionine were used for estimation of the toxicity of L-methionine.
A GLP study for short-term toxicity to daphnia according to guideline OECD 202 (2001-0080-DGO) determined the EC50 for Daphnia magna after 48 h as 324 mg/l D,L-methionine.
The toxicity to fish by D,L-methionine was measured in a GLP guideline study in accordance with OECD 203. The LC50 after 96 h for the fresh water fish Brachydanio rerio was specified >3200 mg/l as all animals were alive at a concentration of 3200 mg/l D,L-methionine.
Toxicity to aquatic algae by D,L-methionine was assessed in a static growth inhibition test (2002-0518-DGO) with the green algae Desmodesmus subspicatus according to OECD 201. The EC50 and NOEC value after 72 h was determined as >1000 mg/l D,L-methionine, demonstrating that a concentration of 1000 mg/l D,L-methionine has no toxic effect on aquatic algae.
The effect of D,L-methionine on the growth of microorganism Pseudomonas putida was determined in a GLP study (89-0130-DGO) with an EC50 of 10000 mg/l. Dawson and Jenkins (1950) showed that methionine is rapidly oxidized by activated sludge and showed no toxic effects to the microorganisms of activated sludge.
Furthermore, 20 mM D,L-methionine showed no toxic effect to the tubificid worm Tubifex tubifex and even decreases the toxicity of copper to the tubificid worm (Khangarot and Rathore 2004).
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