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Diss Factsheets
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EC number: 453-460-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Remarks:
- Other density types indicated (migrated information): density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 November 2015 to 29 January 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
- Type:
- density
- Density:
- 952 kg/m³
- Temp.:
- 20 °C
- Key result
- Type:
- relative density
- Density:
- 0.952
- Temp.:
- 20 °C
- Conclusions:
- The density of the test item was determined to be 952 kg/m3 at 20.0 ± 0.5 °C with a relative density of 0.952.
- Executive summary:
GUIDELINE
Relative density was determined using the pycnometer method and a procedure designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.
RESULTS
The density of the test item was determined to be 952 kg/m3 at 20.0 ± 0.5 °C with a relative density of 0.952.
- Endpoint:
- density
- Remarks:
- Density types indicated (migrated information): other: specific gravity; density
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012-12-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM D4052-11 Standard Test Method for Density, Relative Density, and API Gravity of Liquids by Digital Density Meter
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- oscillating densitimeter
- Type:
- other: specific gravity
- Density:
- 0.905
- Temp.:
- 15.6 °C
- Type:
- density
- Density:
- 904 kg/m³
- Temp.:
- 15.6 °C
- Conclusions:
- The specific gravity of the test substance is 0.9049 at 15.6 °C and 0.9014 at 20 °C (calculated);
Conversion to density (density of water at 15.6°C = 0.999012) = 904 kg/m3 - Executive summary:
The specific gravity of the test substance, determined by procedures given in ASTM D4052, is 0.9049 at 15.6 deg. C
Density is 0.9014 at 20 °C calculated by using this equation: Density at 20 oC = Density at15.6 oC – (20-15.6) x 0.00079
Conversion to density (density of water at 15.6°C = 0.999012) = 904 kg/m3
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Certificate of Analysis.
- Qualifier:
- according to guideline
- Guideline:
- other: FR020140
- GLP compliance:
- no
- Type:
- density
- Density:
- 979 kg/m³
- Temp.:
- 20 °C
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Certificate of Analysis.
- Qualifier:
- according to guideline
- Guideline:
- other: UIL 1018
- Principles of method if other than guideline:
- No more details available about method.
- GLP compliance:
- no
- Type of method:
- other: measured
- Type:
- density
- Density:
- 940 kg/m³
- Temp.:
- 20 °C
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method SPARC online calculator.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Calculation based on SPARC online calculator http://ibmlc2.chem.uga.edu/sparc/, University of Georgia, USA.
- GLP compliance:
- no
- Remarks:
- Calculation
- Type of method:
- other: estimated by calculation
- Type:
- density
- Density:
- 980 - 1 060 kg/m³
- Temp.:
- 20 °C
- Endpoint:
- density
- Remarks:
- Density types indicated (migrated information): other: specific gravity; density
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Type of method:
- oscillating densitimeter
- Type:
- other: specific gravity
- Density:
- 0.905
- Temp.:
- 15.6 °C
- Type:
- density
- Density:
- 904 kg/m³
- Temp.:
- 15.6 °C
- Conclusions:
- The specific gravity of the test substance is 0.9049 at 15.6 °C and 0.9014 at 20 °C (calculated);
Conversion to density (density of water at 15.6°C = 0.999012) = 904 kg/m3 - Executive summary:
The specific gravity of the test substance, determined by procedures given in ASTM D4052, is 0.9049 at 15.6 deg. C
Density is 0.9014 at 20 °C calculated by using this equation: Density at 20 oC = Density at15.6 oC – (20-15.6) x 0.00079
Conversion to density (density of water at 15.6°C = 0.999012) = 904 kg/m3
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- density
- Density:
- 979 kg/m³
- Temp.:
- 20 °C
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- density
- Density:
- 940 kg/m³
- Temp.:
- 20 °C
- Endpoint:
- density
- Remarks:
- density
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Type:
- density
- Density:
- 980 - 1 060 kg/m³
- Temp.:
- 20 °C
Referenceopen allclose all
Table 4 – Determination of density |
||
Measurement |
Determination |
|
1 |
2 |
|
Mass of pycnometer (g) |
17.3531 |
17.3275 |
Mass of pycnometer and distilled water at 20 °C (g) |
27.5629 |
27.5066 |
Mass of pycnometer and test item at 20 °C (g) |
27.0682 |
27.0544 |
Density of water at 20 °C (kg/m3) |
998.20 |
998.20 |
Density (kg/m3) |
950 |
954 |
Mean density |
952 kg/m3 |
|
Mean relative density |
0.952 |
|
Temperature |
20.0 ± 0.5 °C |
Description of key information
The density of the test item was determined to be 952 kg/m3 at 20.0 ± 0.5 °C with a relative density of 0.952 (OECD 109 and EU Method A.3).
Key value for chemical safety assessment
- Relative density at 20C:
- 0.952
Additional information
GUIDELINE
Relative density was determined using the pycnometer method and a procedure designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.
RESULTS
The density of the test item was determined to be 952 kg/m3 at 20.0 ± 0.5 °C with a relative density of 0.952.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.