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Diss Factsheets
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EC number: 453-460-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Surface tension
Administrative data
Link to relevant study record(s)
- Endpoint:
- surface tension
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2013-04-10 to 2013-06-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- ring method
- Surface tension:
- 72.9 mN/m
- Temp.:
- 21.8 °C
- Conc.:
- 90 vol%
- Remarks on result:
- other: Not surface active
- Conclusions:
- The surface tension of a 90 % saturated solution in water has been determined to be 72.9 ± 0.5 mN/m at 21.8 ± 0.5 °C. The test item was considered to be not surface-active.
- Executive summary:
Guideline
Method A5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Method
Ring method
Result
The surface tension of a 90 % saturated solution in water has been determined to be 72.9 ± 0.5 mN/m at 21.8 ± 0.5 °C.
Conclusion
The test item was considered to be not surface-active.
- Endpoint:
- surface tension
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Surface tension:
- 72.9 mN/m
- Temp.:
- 21.8 °C
- Conc.:
- 90 vol%
- Remarks on result:
- other: Not surface active
- Conclusions:
- The surface tension of a 90 % saturated solution in water has been determined to be 72.9 ± 0.5 mN/m at 21.8 ± 0.5 °C. The test item was considered to be not surface-active.
- Executive summary:
Guideline
Method A5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Method
Ring method
Result
The surface tension of a 90 % saturated solution in water has been determined to be 72.9 ± 0.5 mN/m at 21.8 ± 0.5 °C.
Conclusion
The test item was considered to be not surface-active.
Referenceopen allclose all
Surface tension (corrected): reading x calibration factor
Sample A (corrected): 73.1 mN/m x 0.996 = 72.8 mN/m
Sample B (corrected): 73.4 mN/m x 0.996 = 73.1 mN/m
Mean: 72.9 mN/m
Temperature: 21.8 ± 0.5 °C
Solution pH: Sample 1 = 5.6
Sample 2 = 5.6
After the equilibration period, each sample was noted to contain excess, undissolved test item at the surface of the solution; whereas, after centrifugation, each sample (supernatant) was noted to be a clear, colorless solution free from excess, undissolved test item.
A platinum ring with a reduced circumference of 4 cm was used, whereas the guidelines specify 6 cm. Once calibrated, the balance and ring assembly used in this test give a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m). This procedure with respect to the reduced ring dimensions has been considered not to have affected the integrity of the test.
As each (corrected) surface tension value was within 0.5 mN/m of the mean (corrected) value, the mean (corrected) value was considered to be acceptable as the endpoint of the test.
According to criteria mentioned in Method A6, substances showing a surface tension lower than 60 mN/m under the conditions of this method should be regarded as being surface active.
Surface tension (corrected): reading x calibration factor
Sample A (corrected): 73.1 mN/m x 0.996 = 72.8 mN/m
Sample B (corrected): 73.4 mN/m x 0.996 = 73.1 mN/m
Mean: 72.9 mN/m
Temperature: 21.8 ± 0.5 °C
Solution pH: Sample 1 = 5.6
Sample 2 = 5.6
After the equilibration period, each sample was noted to contain excess, undissolved test item at the surface of the solution; whereas, after centrifugation, each sample (supernatant) was noted to be a clear, colorless solution free from excess, undissolved test item.
A platinum ring with a reduced circumference of 4 cm was used, whereas the guidelines specify 6 cm. Once calibrated, the balance and ring assembly used in this test give a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m). This procedure with respect to the reduced ring dimensions has been considered not to have affected the integrity of the test.
As each (corrected) surface tension value was within 0.5 mN/m of the mean (corrected) value, the mean (corrected) value was considered to be acceptable as the endpoint of the test.
According to criteria mentioned in Method A6, substances showing a surface tension lower than 60 mN/m under the conditions of this method should be regarded as being surface active.
Description of key information
Determination of surface tension is not required because water solubility of the test item has been shown to be < 1E-06 g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
Additional information
Water solubility of the test item was determined to be < 1E-06 g/L of solution at 20.0 ± 0.5 °C and, in accordance with REACH Annex VII, Column 2, surface tension does not need to be investigated because solubility in water is below 1 mg/L at 20 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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