Registration Dossier
Registration Dossier
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EC number: 200-891-8 | CAS number: 75-68-3
Endpoint summary
Administrative data
Description of key information
Additional information
Short term tests are available for 1-chloro-1,1-difluoroethane for fish Poecilia reticulata and Daphnia magna, showing a 96-h EC50 of 220 mg/L (Duphar 1990a) and an 48-h EC50 of 160 mg/L (Duphar 1990b) respectively. No experimental data is available for algae.
Aquatic toxicity testing with gases often lead to invalid results because of the technical difficulties associated with the physical state of the substances. Commercially available HFCs and HCFCs share common physicochemical and environmental fate. Although it is not possible to identify clear structure-related trends along the series, the common features present in the ecotoxicological profiles of these substances demonstrate that category approach is justified for these two groups of substances.
That is the reason why we proposed to use category approach and fill the missing data by using QSARs data and/or read-across. Besides, the exposition of the aquatic compartment will be very low based upon the volatility of the considered substances. In other words, fluorocarbons will partition in the atmospheric compartment very quickly. In other words, the aquatic compartment is not the final environmental compartment of the concerned substances. Last but not the least, in this approach we use each time the most conservative approach in order to fill the missing data with data that would’ not underestimate the hazard for the aquatic compartment.
The justification of the category approach is attached to this endpoint summary.
In this framework, the data obtained for 1,1 -dichloro-2,2,2 -trifluoromethane (CAS: 306 -83 -2) was used in order to estimate the toxicity of 1-chloro-1,1-difluoroethane for freshwater algae. This toxicity was estimated to be 96h - ECgrowth50 = 96.6 mg/l.
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