Registration Dossier
Registration Dossier
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EC number: 225-035-0 | CAS number: 4621-04-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Human Maximization Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-isopropylcyclohexanol
- EC Number:
- 225-035-0
- EC Name:
- 4-isopropylcyclohexanol
- Cas Number:
- 4621-04-9
- Molecular formula:
- C9H18O
- IUPAC Name:
- 4-(propan-2-yl)cyclohexan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: Humans
Test system
- Type of coverage:
- other: Closed patch test
- Preparation of test site:
- not specified
- Amount / concentration applied:
- 5% Folrosia in aqueous sodium lauryl sulfate
- Duration of treatment / exposure:
- 48h
- Observation period:
- 48hr, 72hr
- Number of animals:
- 25 human subjects completed the study.
- Details on study design:
- Human patch test.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Observation of contact-sensitization
- Basis:
- mean
- Time point:
- other: 48hr/72hr
- Score:
- 0
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
There were no instances of contact-sensitization from Folrosia on the Maximization Test and no incidences of skin irritation.
Therefore it is concluded that it is unlikely that Folrosia would present a danger of contact-sensitizastion in normal, intended use.
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