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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 5, 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Principles of method if other than guideline:
The test was performed according to the SOP - STR 071 protocol. Laser light scattering. The particle size distribution was analyzed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measures the size of particles. It measures the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
ca. 23.344 µm
St. dev.:
0
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment. St. Deviation not reported.
Percentile:
D50
Mean:
ca. 56.353 µm
St. dev.:
0
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment. St. Deviation not reported.
Percentile:
D90
Mean:
ca. 111.234 µm
St. dev.:
0
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment. St. Deviation not reported.
Conclusions:
The substance particle size distribution was measured by light scattering and the results are D10 = 23.344 µm, D50 = 56.353 µm and D90 = 111.234 µm.
Executive summary:

The substance particle size distribution was measured by light scattering and the results are D10 = 23.344 µm, D50 = 56.353 µm and D90 = 111.234 µm.

Description of key information

D50 = 56.353 µm

Additional information