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EC number: 268-750-3
CAS number: 68134-38-3
Body weight gains and clinical signs:
The body weight gains of the animals were not impaired. Moreover, the treated animals showed no clinical signs of intoxication throughout the study.
Irritations during the sensitization phase:
No signs of irritation occurred during the observation period. The skin surface of the treatment group was discolored orange.
Dermal challenge treatment:
No positive skin response was observed in the control and the treatment group 24 and 48 hours after removal of the occlusive bandage. The skin-surface of the animals was discolored orange.
In a dermal sensitization study (OECD 406) with the test item 20 female Pirbright-White guinea pigs were tested using the method of Buehler. Dermal induction was performed using 0.5 g of the test item moistened with 0.5 mL deionized water. Challenge of the treatment and control group were carried out with 0.5 g of the test item moistened with 0.5 mL deionized water. Under the conditions of the present study, none of the twenty treated guinea pigs showed a positive skin response 24 hours and 48 hours after the challenge procedure. Thus, the test item is not a dermal sensitizer.
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