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Diss Factsheets
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EC number: 700-834-1 | CAS number: 9041-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There were several reports are available investigating effects of the test substance in exposure related ovservations in humans, weight of evidence.
Additional information
To conclude, inhalation of ≤32,000 International Units, as a lower respiratory tract dose, of unfractionated test substance did not affect pulmonary function. A dose-dependant anticoagulant effect could be demonstrated on the circulating blood (antifactor-Xa, activated partial thromboplastin time) and the endothelial cells as release of tissue factor pathway inhibitor. However, these changes were small and of no clinical relevance. The authors therefore consider inhalation of test substance in these or smaller doses to be safe with respect to pulmonary function and systemic anticoagulation. (Bendstrup, 2000)
These studies indicate that the test substance administration can be associated with complement-mediated platelet injury. The dose-dependent nature of this process may account for the occurrence of thrombocytopenia in some of these patients. (Cines, 1980)
The findings suggest that hyperkalemia can develop with the use of low-dose test substance, within seven days of initiating test substance therapy, and that patients with diabetes mellitus or chronic renal insufficiency are especially predisposed to this complication. (Edes, 1984)
The test substance-induced hyperkalemia is a potentially life threatening problem. (Busch, 1987)
Skin reaction to test substance is a recognised complication of subcutaneous test substance. The reaction is due to the test substance component and thought to be a localised arthus reaction or test substance induced, immune mediated platelet aggregation. (Nair, 1997)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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