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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The key study was conducted according to a protocol similar to OECD test guideline, with acceptable restrictions. The study was not compliant with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
groups of only three male and three female animals per dose; observation period was less than 14 days.
GLP compliance:
no
Remarks:
The study pre-dates GLP
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
not specified

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Charles River France

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
peanut oil
Details on oral exposure:
No details provided in report.
Doses:
670, 1000, 1500, 2250 and 3370 mg/kg bw
No. of animals per sex per dose:
3 males and 3 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 700 mg/kg bw
Based on:
not specified
Mortality:
No mortalities occurred in the 670 and 1000 mg/kg bw groups. After ten days, the mortalities in the other groups were as follows: 1500 mg/kg bw three out of six; 2250 mg/kg bw four out of six; 3370 mg/kg bw six out of six .
Clinical signs:
At all doses tested the animals showed slight sedation, stiffness and increased sensitivity to sound and touch. At toxic doses death followed tonic convulsions, appearing during the first 24 hours. Animals which survived were symptom-free after two days.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In an acute toxicity study, 2,2,4,4,6,6-hexamethylcyclotrisilazane was administered orally to groups of three male and three female mice at doses of 670, 1000, 1500, 2250 and 3370 mg/kg bw. The reporting of the study was limited. It was concluded that the LD50 was 1700 mg/kg bw.