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EC number: 213-773-6 | CAS number: 1009-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- the animals were exposed to test substance for 24 hours, observation was not continued for 14 days to determine reversibility
- GLP compliance:
- no
- Remarks:
- The study pre-dates GLP
Test material
- Reference substance name:
- 2,2,4,4,6,6-hexamethylcyclotisilazane
- IUPAC Name:
- 2,2,4,4,6,6-hexamethylcyclotisilazane
- Reference substance name:
- 2,2,4,4,6,6-hexamethylcyclotrisilazane
- EC Number:
- 213-773-6
- EC Name:
- 2,2,4,4,6,6-hexamethylcyclotrisilazane
- Cas Number:
- 1009-93-4
- Molecular formula:
- C6H21N3Si3
- IUPAC Name:
- 2,2,4,4,6,6-hexamethyl-1,3,5,2,4,6-triazatrisilinane
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Very few details given in study report
Weight of animals at study initiation: 2.3 to 3.0 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: The test substance was applied unchanged or as a 1%, 3%, 10% or 30% solution in peanut oil
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): 1%, 3%, 10% or 30% solution in peanut oil
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- six rabbits per concentration
- Details on study design:
- TEST SITE
- Area of exposure: approximately 3 cm in diameter, therefore 4.5 cm²
- % coverage: no data
- Type of wrap if used: The test substance was applied on an aluminium disk kept in place with adhesive tape and a bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no information
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- mean
- Remarks:
- the erythema score for every animal was 4
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- Undiluted test material applied to intact skin
- Basis:
- mean
- Remarks:
- the erythema score for every animal was 4
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #1
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #2
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #3
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #4
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- probability of weak irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #5
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- animal #6
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- Undiluted test substance applied to intact skin
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The data for lower concentrations showed a similar pattern to that seen with undiluted test substance, reducing in severity with reducing concentration:
30%: erythema 4 in all animals at 24 and 72 hours; edema 0 at 24 and 72 hours;
10%: erythema 4 in five out of six animals at 24, decreasing to 4 at 72 hours, no erythema in one rabbit; edema 0 at 24 and 72 hours;
3%: no erythema or edema observed in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- 2,2,4,4,6,6-hexamethylcyclotrisilazane has been tested in a study similar to an OECD 404, prior to OECD GLP criteria being adopted. Application of undiluted substance to the intact skin of six New Zealand white rabbits for 24 hours resulted an erythema score of 4/4 in all animals at 24 and 72 hours. No further observations were made and there is no information on reversibilty of the observed erythema. Edema (score 1/4) was observed in three out of six animals at 24 hours, fully reversible within 72 hours. Test substance diluted in oil also resulted in erythema, but not edema. A 30% solution in peanut oil also resulted an erythema score of 4/4 in all animals at 24 and 72 hours. A 10% solution caused erythema in five out of six rabbits, with a score of 3/4 at 24 hours increasing to 4/4 at 72 hours. No erythema was observed at 24 hours after application of a 3% solution. It is concluded that the substance is irritating to the skin.
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