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EC number: 203-406-8 | CAS number: 106-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
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- Nanomaterial surface chemistry
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- Nanomaterial pour density
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Modelling Database - ECOSAR v.1.11
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: green algae
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- Estimated data
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 209.879 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Neutral Organic SAR (Baseline Toxicity)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The estimated EC50 values for aquatic algae after 96 hours was 1209.879 mg/l on the basis of growth rate.
- Executive summary:
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours EC50 was estimated to be 1209.879 mg/l on green algae for substance 4-Piperidinol, 1-methyl- (CAS no. 106 -52 -5) with growth inhibition effects.Thus, based on this value, it can be concluded that the substance can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Reference
Description of key information
The median Effective concentration (EC50) value for 1-methylpiperidin-4-ol on Pseudokirchneriella subcapitata in a 72 hour study was estimated to be 110.386 mg/L on the basis of effects on growth rate.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 110.386 mg/L
Additional information
Predicted data for the test chemical 4-Piperidinol, 1-methyl- (CAS No. 106-52-5) and the studies of its read across substance were reviewed to summarize the following information:
The key study is based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 1-methylpiperidin-4-ol (CAS no. 106 -52 -5). EC50 value was estimated to be 110.386 mg/l for Pseudokirchneriella subcapitata for 72 h duration. Based on this value it can be concluded that the substance 1-methylpiperidin-4-ol is considered to be non-toxic to aquatic environment and can be considered to be not classified as per the CLP classification criteria.
Supporting the above data, QSAR prediction was done using the EPI Suite ECOSAR version 1.10 (EPI Suite, 2016), the 96 hours EC50 was estimated to be 1209.879 mg/l on green algae for substance 4-Piperidinol, 1-methyl- (CAS no. 106 -52 -5) with growth inhibition effects.
In an experimental study for RA CAS 105-59-9, Short term toxicity to Desmodesmus subspicatus study was carried out for 72 hrs (SIDS INITIAL ASSESSMENT PROFILE, CoCAM2, Pg. no. 17-19, April 2012). The test organism used for the study was Desmodesmus subspicatus. Based on growth rate of the test organism Desmodesmus subspicatus, the 72 hrs ErC50 value was determined to be 175.7 mg/l.
For same RA CAS 105-59-9 similar experimental Short term toxicity to Skeletonema costatum study was carried out for 72 hrs (SIDS INITIAL ASSESSMENT PROFILE, CoCAM2, Pg. no. 17-19, April 2012). The test organism used for the study was Skeletonema costatum. Based on growth rate of the test organism Skeletonema costatum, the 72 hrs ErC50 and EbC50 value was determined to be 410 and 110 mg/l, respectively.
Based
on the overall reported results for target and read across substance, it
can be concluded that the substance 4-Piperidinol, 1-methyl-can be
considered as non-toxic to aquatic organisms and thus cannot be
classified as hazardous as per the CLP criteria.
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