Registration Dossier
Registration Dossier
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EC number: 278-674-2 | CAS number: 77365-64-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 30, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- not specified
- Type of method:
- flask method
- Water solubility:
- ca. 441 170 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 3.5
- Remarks on result:
- other: mean of two measurements
- Details on results:
- Reference solutions were measured in the spectrophotometer in quantitative mode, thus generating a calibration curve smooth and linear at every concentration.Two measurement were performed, at 24 and after 48 hs. Measured results were the following:
Final test at 24h: 443060 mg/L
Final test at 48h: 439270 mg/L - Conclusions:
- Water solubility = 441170 mg/l
The tested substance is considered very soluble. - Executive summary:
Method
Water solubility was determined by OECD Guideline 105 (Water solubility), adopted 27.05.95.
A preliminary solubility test was performed: a preliminary solution was prepared.
1.5 mL of the saturated solution was taken from this solutionand separated by centrifugation. The overnanatant was weighed and dissolved with a double distilled water in 250 mL, keeping the solution for 1 h in a thermostatic bath at 20 °C, then adjusting volume.
Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements. TheWavelength chosen was 542.5 nm.
Two measurement were performed on the final solution, at 24 and after 48 hs.
Results
Final test at 24h: 443.06 g/L
Final test at 48h: 439.27 g/L
Conclusion
The tested substance is considered very soluble (water solubility = 441170 mg/L, mean)
Reference
Preliminary solubility test: Reference samples and extract were first measured in the range 190 / 800 nm, so as to choose the right wavelength for quantitative measurements.Wavelength chosen: 542.5 nm
Description of key information
Water Solubility = 441170 mg/l
Key value for chemical safety assessment
- Water solubility:
- 441 170 mg/L
- at the temperature of:
- 20 °C
Additional information
Water solubility was determined by OECD Guideline 105 (Water solubility), adopted 27.05.95.
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