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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials – Geranyl Isobutyrate
Author:
D. L. J. OPDYKE
Year:
1975
Bibliographic source:
Fd Cosmet. Toxicol, Vol. 13, pp. 449-457, 1975

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the dermal irritation potential of Geranyl isobutyrate in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material :3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate
- Molecular formula: C14H24O2
- Molecular weight: 224.342 g/mol
- Smiles notation : C(OC\C=C(\CC\C=C(/C)C)C)(C(C)C)=O
- InChl : 1S/C14H24O2/c1-11(2)7-6-8-13(5)9-10-16-14(15)12(3)4/h7,9,12H,6,8,10H2,1-5H3/b13-9+
- Substance type:Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: 3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate
- Common Name: Geranyl isobutyrate
- Molecular formula: C14H24O2
- Molecular weight: 224.342 g/mol
- Smiles notation: C(OC\C=C(\CC\C=C(/C)C)C)(C(C)C)=O
- InChl: 1S/C14H24O2/c1-11(2)7-6-8-13(5)9-10-16-14(15)12(3)4/h7,9,12H,6,8,10H2,1-5H3/b13-9+
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
full strength
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritant / corrosive response data:
mild irritation observed

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Conclusions:
Mild irritation occurred after 24 hours.
Hence, Geranyl isobutyrate (2345-26-8) was considered to be mildly irritating to rabbit skin.
Executive summary:

A skin irritation study was performed in rabbits to assess the irritation potential of Geranyl isobutyrate.

Geranyl isobutyrate was applied full strength under occlusion to intact and abraded rabbit skin. The rabbits were exposed for 24 hours and signs of irritation were observed. Mild irritation occurred after 24 hours.

Hence,Geranyl isobutyrate (2345-26-8) was considered to bemildly irritating to rabbit skin.