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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

In vitro studies:

Tert-butylamine was tested for mutagenicity using the Salmonella/microsome preincubation assay using the standard protocol approved by the National Toxicology Program. Tert-butylamine was tested at doses of 0, 33, 100, 333, 1000, 1666 and 3333 ug/plate in 4 Salmonella typhimurium strains (TA1535, TA1537, TA98, and TA100) in the presence and absence of rat or hamster liver S-9. Tert-butylamine was negative in these tests and the highest ineffective dose tested in any Salmonella typhimurium strain was 1000 mg/plate (Zeiger et al. 1987; Val. 2). A further study (TA1538, TA1537, TA1535, TA98, and TA100) validated these negative results in the Ames test (Monsanto 1977; Val. 4).


In vivo studies:

No in vivo studies available

Short description of key information:
In vitro studies:
Ames-Test: negative (NTP standard protocol )

In vivo studies: No in vivo studies available

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Two Ames-tests, with or without metabolic activation through S9 -mix failed to provide any evidence for a mutagenic effect of tert-butylamine.