Registration Dossier
Registration Dossier
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EC number: 245-509-0 | CAS number: 23235-61-2
Endpoint summary
Administrative data
Description of key information
The substance Ditrimethylolpropane is inherently and ultimately biodegradable.
A hydrolysis study conducted according to OECD Guideline 111 showed that less than 10% degradation occurred at pH 4, 7 and 9 at 50°C during initial testing. Further testing was therefore not conducted, and Di(trimethylolpropane) was concluded to be hydrolytically stable (Hugill and Markowicz, 2016).
The logKow of di-trimethylolpropane is reported to be 0.88 (see Section 4.7, partition coefficient). According to Column 2 of Annex IX of the REACH Regulation, no study is required if the logKow is below the trigger of 3 as the substance can be expected to have a low potential for bioaccumulation.
Based on the Log Pow value (OECD 117, 0.88), the substance can be expected to have a low potential for adsorption. According to Column 2 of Annex VIII of the REACH regulation, no study is required if the logPow is below the trigger of 3 as the substance can be expected to have a low potential for adsorption.
According to Column 9.2 of REACH Annex IX, further degradation testing (including simulation testing in appropriate media, e.g. water, sediment or soil) shall only be considered if it is demonstrated in the chemical safety assessment (according to Annex I) that it is necessary to further investigate the degradation of the substance and its degradation products. Available experimental ecotoxicity test data has demonstrated very low ecotoxicity of di-trimethylolpropane (fish 96 hour LC50: >1000 mg/L; aquatic invertebrate 48 hour EC50: 3560 mg/L; algae 72 hour EC50: >1000 mg/L). No adverse effects were observed at the highest recommended concentrations tested, thereby indicating that no hazard has been identified and that PNEC values would not need to be derived (ECHA, 2011) (although for completeness, PNECs have been derived regardless). Moreover, the substance does not fulfil the criteria for being regarded as PBT or vPvB, nor is direct release of the substance into the environment anticipated. Consequently, according to the chemical safety assessment performed according to Article 14(3) in connection with Annex I section 3 (Environmental Hazard Assessment), no environmental risk assessment is required under REACH. It is therefore not considered necessary to further investigate the degradation of di-trimethylolpropane or its degradation products in water and sediment or soil, as per Column 9.2 of REACH Annex IX.
Additional information
ECHA, 2011. ECHA Guidance on information requirements and chemical safety assessment Part B: Hazard Assessment. Helsinki: ECHA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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