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EC number: 245-509-0 | CAS number: 23235-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 June 1992 - 14 August 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD test guidelines and a statement of GLP compliance is included in the study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol]
- EC Number:
- 245-509-0
- EC Name:
- 2,2'-[oxybis(methylene)]bis[2-ethylpropane-1,3-diol]
- Cas Number:
- 23235-61-2
- Molecular formula:
- C12H26O5
- IUPAC Name:
- 2-ethyl-2-{[2-ethyl-3-hydroxy-2-(hydroxymethyl)propoxy]methyl}propane-1,3-diol
- Reference substance name:
- 3,3,7,7-tetrahydroximethyl-5-oxanone
- IUPAC Name:
- 3,3,7,7-tetrahydroximethyl-5-oxanone
- Reference substance name:
- Di-Trimethylolpropane
- IUPAC Name:
- Di-Trimethylolpropane
- Details on test material:
- - Name of test material (as cited in study report): Di-trimethylolpropane, Di-TMP and 3,3,7,7-tetrahydroximethyl-5-oxanone (reported as ditrimethylolpropane in this summary)
- Lot/batch No.: 90128
- Stability under test conditions: 1% water solution stable for one week at 4ºC
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- A 10000 mg/L stock solution was used to prepare the test media.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Toxicon's culture which originates from NIVA, Oslo, Norway.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- Not applicable
- Test temperature:
- Measured temperature at start = 23.0; temperature at end of test = 25.0ºC.
- pH:
- pH at start of test (recorded) = 8.1 - 8.2; pH at end of test = 8.9 - 9.5.
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0 (control group) and 1000 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 250 mL glass E-Bottles - 100 mL fill volume (therefore 150 mL headspace)
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates):5
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH: Not required - pH in controls and test solutions were within expected range.
- Photoperiod: Continuous illumination
- Light intensity and quality: 100µEm-2s-1
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Chlorophyll measurement: Samples analysed for chlorophyll a fluorescence with samples taken at 0, 24, 48, and 72 hours.
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: In a preliminary test it was found that the growth inhibition at 500 and 1000 mg/L was very low. - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks:
- (Inhibition)
- Details on results:
- The growth rates (u) in the control and 1000 mg/L treatment were 1.10 and 0.96. The % inhibition in the 1000 mg/L treatment was 12.5%.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Graphical estimation of the EC50
Growth rate calculated as per the OECD guidelines
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 72 hours algal growth inhibition limit study, test species Selenastrum capricornutum, was performed to determine the toxic effects of the test substance ditrimethylolpropane. The test was conducted according to OECD test guideline 201, and performed to GLP. The 72 hour EC50 value, based on growth rate, was observed to be >1000 mg/L (the highest nominal exposure concentration tested).
- Executive summary:
A 72 hours algal growth inhibition limit study, test species Selenastrum capricornutum, was performed to determine the toxic effects of the test substance ditrimethylolpropane. The test was conducted according to OECD test guideline 201, and performed to GLP. The 72 hour EC50 value, based on growth rate, was observed to be >1000 mg/L (the highest nominal exposure concentration tested).
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