Ethanone, 1-[4-bromo-3-(chloromethyl)phenyl]-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-[4-bromo-3-(chloromethyl)phenyl]ethan-1-one

EC Number:

942-637-5

Cas Number:

1844064-90-9

Molecular formula:

C9H8BrClO

IUPAC Name:

1-[4-bromo-3-(chloromethyl)phenyl]ethan-1-one

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

All animals used were allowed to acclimatise to the laboratory conditions for at least 5 days.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

cotton seed oil

Details on oral exposure:

The test item was suspended with the vehicle cottonseed oil at a concentration of 0.2 g/mL (dose of 2000 mg/kg) and of 0.03 g/ml (dose of 300 mg/kg) and administered at a dose volume of 10 mL/kg.

Doses:

2000 and 300 mg/kg body weight

No. of animals per sex per dose:

3

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 300 - < 2 000 mg/kg bw

Based on:

test mat.

Mortality:

All animals of the first step treated with the test item at a dose of 2000 mg/kg died before study completion date. One animal dead spontaneously on the day of the treatment and two had to be sacrificed for ethical reasons on day 2 post-application.

Clinical signs:

other: The most relevant clinical findings in the animals treated with the test item at a dose of 2000 mg/kg bw were reduced spontaneous activity, bradykinesia, piloerection, eyes closed, kyphosis, ataxia, salivation, eyes half closed, catalepsis, moving the bed

Gross pathology:

At necropsy, no macroscopic findings were observed in any animal of both steps.
Macroscopic findings of animals not having survived until the end of the observation period: Necropsy revealed a gaseous distension of the stomach, dark discoloured duodenum and jejunum.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

On the basis of the test results the substance should be classified into category 4, Harmful if ingested.
LD50 cut-off (rat): 500 mg/ kg bw