Butyl O-acetylricinoleate

Endpoint summary

Description of key information

Bioaccumulation: aquatic / sediment:

From BCFBAF (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for butyl 12-acetoxyoctadec-9-enoate is 370.7 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that chemical butyl 12-acetoxyoctadec-9-enoate is not expected to be bioaccumulative in fish and the food chain.

Additional information

Bioaccumulation: aquatic / sediment:

Four studies including predicted data from validated model and experimental results for bioaccumulation (BCF) endpoint of test substancebutyl 12-acetoxyoctadec-9-enoate(CAS no.140-04-5) with relevant read across which is structurally similar to target were summarized as follows:

 

First estimation using the BCFBAF (v3.00) model of EPI suite indicate the bio concentration factor (BCF) fo rbutyl 12-acetoxyoctadec-9-enoate as 370.7 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that chemicalbutyl 12-acetoxyoctadec-9-enoateis not expected to be bioaccumulative in fish and the food chain.

Another prediction database i.e PBT profiler for target also indicate that the Bioaccumulation factor (BCF) for test substance butyl 12-acetoxyoctadec-9-enoate was estimated to be 370 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical 12-acetoxyoctadec-9-enoate is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Above target predictions are supported by experimental result of read across chemical Bis(2-ethylhexyl)ester hexanedioic acid (Cas no.103 -23 -1) which suggest 28-d uptake and 14-d depuration bioconcentration study of the bluegill sunfish was conducted following U.S. EPA and ASTM procedures. During study, muscle filet and viscera portions were analyzed. Individual samples were converted to 14 CO2 by oxidation/combustion in a Packard 306B Tricarb Sample Oxidizer. Radioassay of the combustion gases were performed by liquid scintillation counting. The diluent water consisted of well water with a hardness of 265 ± 10 mg/L, an alkalinity of 350 ± 25 mg/L, a pH of 7.8 to 8.3 and a specific conductance of 700 µ oham/cm. Dissolved oxygen levels ranged from 9.2 to 10.2 mg/L. A Mount and Brungs proportional diluter delivered water and ['4C]DOA in acetone to the test and control aquaria at a rate of 10 replacement volumes per day. The nominal exposure concentration was 0.20 mg/L. Groups of 130 fish was used. The fish were observed initially and every 24 h during the exposure period for mortality and unusual behavior. Water and fish were sampled during the uptake period at 4 h and 1, 3, 7, 14, 21 and 28 d.Samples were counted for 10 min or to a statistical precision of 0.5% at a two-sigma (95%) confidence level. Counting efficiency and sensitivity were 80.4% and 0.0059 ppm, respectively. On day 28 of the exposure period, the addition of the ['4C]DOA test material was terminated and the fish were exposed to flowing uncontaminated well water for an additional 14 d. During this period, water and fish were sampled on days 29, 31, 35, 38 and 42 and analyzed as during the uptake period. At the end of the experimental study based on the Accumulation effect the Bioconcentration factor (BCF) of chemical Bis(2-ethylhexyl)ester hexanedioic acid (Cas no.140-04-1) in Lepomis macrochirus (Bluegill) was obsrerved to be 27 L/kg. (Environmental Toxicology and Chemistry Vol. 5. pp. 777-784. 1986)

Another study for read across i.e acetyltributyl citrate (Cas no. 77-90-7) indicate an estimated BCF of 35 was calculated in fish for acetyl tributyl citrate, using a log Kow of 4.92 and a regression derived equation this BCF suggests the potential for bioconcentration in aquatic organisms is moderate, provided the compound is not metabolized by the organism.(HSDB database;2017)

Thus all above available values for bioaccumulation (BCF) is in the range of 27 to 370 (L/kg or dimensionless) which gives the final conclusion as target substancebutyl 12-acetoxyoctadec-9-enoate(Cas no.140-04-5) is non Bioaccumulative in aquatic environment.