Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
key study
Study period:
2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A scientifically sound paper

Data source

Reference
Reference Type:
publication
Title:
Chemical Burns Caused by Trifluoroacetic Acid
Author:
Dahlin L et al
Year:
2013
Bibliographic source:
Contact Dermatitis 69, 176-180
Report Date:
2012

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
case reports
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 5
- Sex: male and female
- Age: 22 - 48 years
- Race: not indicated, not relevant
Ethical approval:
not applicable
Route of exposure:
dermal
Reason of exposure:
other: unintential occupational and non-occupational
Examinations:
Five patients with chemical skin burns caused by the test substance were reviewed with regard to the extent of the burn, treatment, blood samples taken, and systemic effects.

Results and discussion

Clinical signs:
No clinical signs were observed except for the expected local skin corrosion effects.

Any other information on results incl. tables

The chemical burns reported were limited (< 1 % of the total body surface). The burns healed as expected for chemical burns caused by acids. None of the patients showed any symptoms or signs that are typical for hydrofluoric acid (the test substance has been suspected to have similar toxic effects as hydrofluoric acid on skin contact).

Applicant's summary and conclusion