Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-929-3 | CAS number: 76-05-1
Endpoint summary
Administrative data
Description of key information
Additional information
As the target substance CAS 76-05-1 (trifluoroacetic acid, TFA) is a strong acid, the ion will be present under environmental conditions. Thus, studies on aquatic toxicity performed with the well water-soluble salt CAS 2923-18-4 (sodium trifluoroacetate, NaTFA) are considered to allow an inference to the aquatic toxicity of TFA. This is supported by ECHA’s Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a: Endpoint specific guidance, paragraph „R.7.6.2.3.2 Procedure for adaptations and testing approaches“, Stage 4, Section (iv), (Version July 2017), where it is stated that the testing of neutral salts of alkine or acidic substances may be appropriate and allows investigation of intrinsic properties at adequate dose levels. Thus, the studies available with the salt of trifluoroacetic acid are considered as sufficient and reliable to cover this endpoint.
Short-term toxicity to fish
No data with the target substance are available. Read-across to the source substance CAS 2923-18-4 (sodium trifluoroacetate, NaTFA) is applied. A study on acute toxicity to fish (Danio rerio) following OECD guideline 203 (GLP, limit test under static conditions) revealed a LC50 (96h) > 1200 mg/L, lying above the maximum concentration tested. The respective NOEC was determined as 1200 mg/L. The substance is thus acutely not harmful to fish.
In addition a test on acute toxicity to fish embryos (FET; no guideline, non-GLP) with zebrafish (Danio rerio) investigating the effect of the target substance CAS 76-05-1 (trifluoroacetic acid, TFA) on the toxicity, the uptake and the effect on the detoxication enzymes in embryos of zebrafish, releaved no evidence of TFA metabolism in fish embryos.
Chronic aquatic toxicity studies on fish are not available.
Short-term toxicity to aquatic invertebrates
No data with the target substance are available. Read-across to the source substance CAS 2923 -18 -4 (sodium trifluoroacetate, NaTFA) is applied.
An acute toxicity study to aquatic invertebrates (Daphnia magna) following OECD guideline 202 (GLP, limit test under static conditions) revealed an EC50 (48h) > 1200 mg/L, lying above the maximum concentration tested. The respective NOEC was determined as 1200 mg/L. The substance is thus acutely not harmful to freshwater invertebrates.
Long-term toxicity to aquatic invertebrates
No data with the target substance are available. Read-across to the source substance CAS 2923 -18 -4 (sodium trifluoroacetate, NaTFA) is applied.
A chronic toxicity study to aquatic invertebrates (Daphnia magna) following OECD guideline 211 (GLP, semi static conditions) revealed a NOEC (21 d) > 25 mg/L based on reproduction .
Toxicity to algae and cyanobacteria
A weight of evidence approach with the read across substance CAS 2923-18-4 (sodium trifluoroacetate, NaTFA) is applied.
The toxicity to aquatic algae and cyanobacteria was investigated using different freshwater and marine water algal species.
The most sensitive freshwater algae species was Pseudokirchneriella subcapitata with an EC50 of 12.0 mg/L and the marine water algae Microcystis aeruginosa with an EC50 greater than 117 mg/L. The algae proved to be the most sensitive species with regard to aquatic toxicity.
Toxicity to aquatic plants other than algae
A study on Duck weed (Lemna gibba) according to ASTM / GLP performed with the source substance CAS 2923-18-4 (sodium trifluoroacetate, NaTFA) over 7 days revealed an EC50 of 1100 mg/L and a NOEC of 300 mg/L (nominal, test material, biomass). Further studies on Myriophyllum sibiricum, Myriophyllum spicatum and Lemna gibba following no guideline / non-GLP) performed with the source substance CAS 2923-18-4 (sodium trifluoroacetate, NaTFA), over 14 days revealed EC50-values in a range of 312.9 - 2505.2 mg/L and NOEC-values in a range of 30 - 300 mg/L.
Toxicity to microorganisms
The 3h-hour EC10 to activated sludge was determined to be > 832 mg trifluoroacetic acid/L.
A read-across to CAS 2923-18-4 (sodium trifluoroacetate, NaTFA) was made (ECHA disseminated dossier, August 2014 for CAS 76-05-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
