Calcium distearate

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authorative database

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two long term toxicity study of aquatic invertebrate for the test chemical :
1. and 2. Long term toxicity study of test material was performed

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Calcium distearate
- Molecular formula (if other than submission substance): C36H70O4.Ca
- Molecular weight (if other than submission substance): 607.023 g/mol
- Smiles notation (if other than submission substance): CCCCCCCCCCCCCCCCCC(=O)O{-}.[Ca]{2+}.O{-}C(=O)CCCCCCCCCCCCCCCCC
- InChl (if other than submission substance): 1S/2C18H36O2.Ca/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
- Substance type: Organic
- Physical state: Solid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

21 d

Duration:

21 d

Dose descriptor:

EC50

Effect conc.:

> 0.55 - < 2 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

reproduction

Duration:

21 d

Dose descriptor:

EC50

Effect conc.:

1.5 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

reproduction

Conclusions:

The test chemical Calcium distearate is not likely to be toxic to invertebrate in long term atleast in the concentration range of 1.5 - 2 mg/l

Executive summary:

Data available for the structurally read across chemicals has been reviewed to determine the short term toxicity of aquatic invertebrate of the test chemical Calcium distearate (1592 -23 -0).The studies are as mentioned below:

1.The long term studyof test material on aquatic invertebrate was performed to evalute its effect on reproduction efficiency of daphnia magna according to OECD Guideline 211 (Daphnia magna Reproduction Test). The EC50 of test material after 21 days was observed to be in the range of 0.66 - 2.1 mg/l . The no effect concentration (NOEC) was observed to be 0.66 mg/l .On the basis of above effect concentration test material can be considered toxic to aquatic enviroment, on the basis of EC50value it can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

2.Long term toxicity of invertebrate study was performed for 21 days according to OECD Guideline 211 (Daphnia magna Reproduction Test). The effect concentration (EC50) observed after 21 days of long term study was observed to be 1.5 mg/l, the NOEC was observed to be 0.48 mg/l. On the basis of above valueit can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

Description of key information

Long term toxicity to aquatic invertebrate:

Data available for the structurally read across chemicals has been reviewed to determine the short term toxicity of aquatic invertebrate of the test chemical Calcium distearate (1592 -23 -0).The studies are as mentioned below:

1.The long term studyof test material on aquatic invertebrate was performed to evalute its effect on reproduction efficiency of daphnia magna according to OECD Guideline 211 (Daphnia magna Reproduction Test). The EC50 of test material after 21 days was observed to be in the range of 0.66 - 2.1 mg/l . The no effect concentration (NOEC) was observed to be 0.66 mg/l .On the basis of above effect concentration test material can be considered toxic to aquatic enviroment, on the basis of EC50value it can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

2.Long term toxicity of invertebrate study was performed for 21 days according to OECD Guideline 211 (Daphnia magna Reproduction Test). The effect concentration (EC50) observed after 21 days of long term study was observed to be 1.5 mg/l, the NOEC was observed to be 0.48 mg/l. On the basis of above valueit can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.5 mg/L

Additional information

Long term toxicity to aquatic invertebrate:

Data available for the structurally read across chemicals has been reviewed to determine the short term toxicity of aquatic invertebrate of the test chemical Calcium distearate (1592 -23 -0).The studies are as mentioned below:

1.The long term studyof test material on aquatic invertebrate was performed to evalute its effect on reproduction efficiency of daphnia magna according to OECD Guideline 211 (Daphnia magna Reproduction Test). The EC50 of test material after 21 days was observed to be in the range of 0.66 - 2.1 mg/l . The no effect concentration (NOEC) was observed to be 0.66 mg/l .On the basis of above effect concentration test material can be considered toxic to aquatic enviroment, on the basis of EC50value it can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

2.Long term toxicity of invertebrate study was performed for 21 days according to OECD Guideline 211 (Daphnia magna Reproduction Test). The effect concentration (EC50) observed after 21 days of long term study was observed to be 1.5 mg/l, the NOEC was observed to be 0.48 mg/l. On the basis of above valueit can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.