Registration Dossier
Registration Dossier
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EC number: 940-393-4 | CAS number: 1702355-94-9
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
Adsorption to solid soil phase is expected.
Key value for chemical safety assessment
Additional information
The adsorption/desorption potential of the compound was assessed with two different QSAR calculations integrated in the US EPA's EPISuite v4.11, KOCWIN v2.00. According to the MCI method the logKoc is 7.2 and the method using the logKow delivered a logKoc of 6.2. These results strongly indicate that the compound will adsorb to the solid soil phase. Moreover, the model calculations are only valid for the uncharged molecule. However, under environmental conditions the compound is present as kationic molecule with one or more positive charges. The presence of negatively charged sediment and soil fractions (humic and fulvic acids) strongly suggest the high adsorption potential already determined for the uncharged molecule.
In conclusion adsorption to the solid soil phase is expected.
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of EC 940-393-4 (Q)SAR results were used for adsorption/desorption. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, further experimental studies on adsorption/desorption are not provided.
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