tert-butyl bromoacetate

Endpoint summary

Additional information

No experimental/literature data substance-specific was found, therefore the assessment of aquatic toxicity was performed using calculation models and available data on structural analogous.

There is strongly disagreement between models, both for fish and invertebrates toxicity. Furthermore the reliability of the calculated value was determined to be low, due to the fact that the substance is outside the applicability domain of the models and a limited number of structurally similar compounds were present in the training set. Model predictions are not reported due to their high incongruence. 

For these reason, a read across approach has been followed; details on the structural analogous have been included in the document attached to the IUCLID section 13.

Data related to the analogous:

Short-term toxicity to fish (Semistatic, Oncorhynchus mykiss): NOEC (96 h) of 56 mg/l; LC50 (96 h) of 240 mg/l

Short-term toxicity to aquatic invertebrates (Static, Daphnia magna): NOEC (48 h) of 180 mg/l; EC50 (48 h) of 350 mg/l

 

Regarding acute (short-term) aquatic toxicity the target substance does not meet the criteria for classification since the median lethal concentration available are well above the threshold value required for classification (i.e. 1 mg/l). Structural differences in the assessed chemicals should not be expected to cause a significant change in toxicological effects that can trigger a classification.

 

For chronic (long-term) aquatic hazard no experimental data are available, thus the classification for long-term aquatic hazard would be based on the acute data available. The substance is not readily biodegradable but it should not be expected to bioaccumulate, since its BCF is lower than 500 and does not show an high affinity to the lipidic phase.

In order to obtain as much information as possible, other structurally and functionally similar substances were searched in the ECHA database for the respective notified classification under the C&L Inventory. None chemical was classified regarding environmental hazard, both acute and chronic. However, it should be noted that the notified classification in the C&L Inventory may not be reliable, since it could not be based on performed experiments, but be derived from simple screening and/or worst case approach.

In conclusion, the tert-butyl bromoacetate should not be expected to fall into none of the chronic categories of the Regulation EC 1272/2008 (CLP), since the LC50 values for both fish and daphnia of the reference read across substance are well above the threshold value of 100 mg/l required for classification.