Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-068-9 | CAS number: 91-44-1
The mean response was computed as the quotient of the sum of the observed reactions and the number of the treated animals.
Modified FCA method and Guinea pig maximization test was performed to evaluate the dermal sensitization potential of the test chemical. 20 female Pirbright White guinea pigs were used for the study.
.In the induction phase, the test compound was dissolved in FCA, 15 mg in 4 ml physiological saline and an emulsion was prepared by mixing the material by mean of a 5ml syringe, until emulsification was completed. The intradermal injections of 6 X 0.10-0.15 ml of this emulsion was applied in a semi circle arc on clipped and shaved shoulder from left to right in such a way that whole quantity of emulsion was used up for 10 animals. This procedure was repeated on 5thand 9thday, leaving a gap of 2-3 cm between the rows of injection. After induction phase of 11 days, animals were challenged by applying 0.05ml of test chemical in a sub irritant concentration, with further dilution to the clipped and shaved skin of the right flank of the treated animals, allowing 5 mins for drying. Control animals were also used. Mean Observations were made after 24, 48 and 72 hours.
No sensitization effects were observed after 72 hours post challenge exposure. Hence, the test chemical can be considered as non -sensitizing to the female guinea pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again