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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 2016 - July 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
4,5-dichloro-2,2,4-trifluoro-5-(trifluoromethoxy) -1,3-dioxolane
EC Number:
605-262-5
Cas Number:
161611-73-0
Molecular formula:
C4F6Cl2O3 C4F6Cl2O3
IUPAC Name:
4,5-dichloro-2,2,4-trifluoro-5-(trifluoromethoxy) -1,3-dioxolane
Test material form:
liquid
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- batch No.of test material: 15-TV09366 - BIN 5/2 BIS C607
- Expiration date of the batch: 31 October 2020

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: 31 October 2020

Results and discussion

Water solubility
Key result
Water solubility:
< 0.01 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
10 mg/L
Incubation duration:
72 h
Temp.:
20 °C
pH:
> 7.3 - < 7.9
Details on results:
Preliminary test:
The content of test item dissolved in the water sample was 4.19 mg/L.

Main study:
No test item was detected upon ten-fold dilution. Therefore, samples were analysed undiluted, too.
Without dilution, observed signals were below the lowest calibration standard. In order to judge whether stirring time sufficed to establish the saturation equilibrium, analysed concentrations were calculated by extrapolation for the samples taken at 4, 5 and 6 days. The maximum difference (MD) after 5 and 6 days stirring was ≤ 15%. Based on these values the saturation equilibrium was considered established.

No test item was detected in the blank water mixture.

Any other information on results incl. tables

Table 1: Main study - water solubility of the test item (ten-fold dilution)

Stirring time

[hours]

Analysed

concentration

[mg/L]

Mean

[mg/L]

MD

[%]

pH

24

n.d.

<0.1*

n.a.

7.4

48

 

 

 

7.3

72

 

 

 

7.9

*As observed signals were below the lowest calibration standard, the result is expressed accordingly. A dilution factor of 10 is taken into account.

Tables 2: Main study - water solubility of the test item (undiluted)

Stirring time

[hours]

Analysed

concentration

[mg/L]

Mean

[mg/L]

MD

[%]

4

0.0030*

<0.01**

4.7***

5

0.0035

 

 

6

0.0037

 

 

*Estimated value, calculated by extrapolation of the calibration curve. Based on these values the saturation equilibrium was considered established.

**As observed signals were below the lowest calibration standard, the result is expressed accordingly. Samples were measured undiluted.

***Calculated for the analysed concentration of after 5 and 6 days stirring time.

Applicant's summary and conclusion

Conclusions:
The water solubility of the test item at 20°C was < 0.01 mg/L.
The pH of the aqueous samples was between 7.3 - 7.9.
Executive summary:

The water solubility of dichloro trifluoro methoxy dioxolane (CAS 161611-73-0) was determined using the slow-stirring flask method according to the OECD guideline 105 (1995) and in compliance with GLP guidelines.

Since, in preliminary test, the water solubility of the test item was found to be < 0.01 g/L, the slow-stirring flask method was chosen for the main study.

In the main test, no test item was detected upon ten-fold dilution therefore samples were also analysed undiluted. In spite of the analysis of undilutes samples, the observed signals were still below the lowest calibration standard (0.01 mg/L). Therefore, the water solubility of the test item at 20°C was considered to be < 0.01 mg/L. The pH of the aqueous samples ten-fold dilution was 7.3 - 7.9.

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