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EC number: 204-569-8 | CAS number: 122-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance material review on 3-phenylpropyl acetate
- Author:
- D. McGinty, C.S. Letizia, A.M. Api
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S457–S461
- Reference Type:
- publication
- Title:
- : A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients
- Author:
- D. Belsito a, D. Bickers a, M. Bruze b, P. Calow c, M.L. Dagli d, A.D. Fryer e, H. Greim f, Y. Miyachi g, J.H. Saurat h, I.G. Sipes
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology 50 (2012) S269–S313
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity study was conducted on rabbits to evaluate toxic nature of 3- Phenylpropyl acetate.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- 3-phenylpropyl acetate
- EC Number:
- 204-569-8
- EC Name:
- 3-phenylpropyl acetate
- Cas Number:
- 122-72-5
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 3-phenylpropyl acetate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):3- Phenylpropyl acetate- Molecular formula (if other than submission substance):C11H14O2- Molecular weight (if other than submission substance):178.23 g/mole- Substance type:Organic- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: dermally
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/Kg
- No. of animals per sex per dose:
- 10 rabbits
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: No data available- Necropsy of survivors performed: No data available- Other examinations performed: Mortality and clinical sign were observed.
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival and clinical sign
- Mortality:
- When treated wtih 5000 mg/kg bw, 1 rabbit were died.
- Clinical signs:
- other: No clinical signs of toxicity were observed in treated rabbits.
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
- Executive summary:
In a acute dermal toxicity study, group of 10 rabbits were treated with 3- Phenylpropyl acetate in the concentration of 5000 mg/Kg orally and observed for 14 days. 1 rabbit were died at 5000 mg/kg bw and no clinical signs of toxicity were observed in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with 3- Phenylpropyl acetate dermally.
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