13-β-ethyl-3-methoxygona-2,5(10)-dien-17-one

Stability: thermal, sunlight, metals

Link to relevant study record(s)

Reference

Endpoint:

stability: thermal, sunlight, metals, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

other: UN-MTC Procedure N.4

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: UN-MTC Procedure H.4

Deviations:

no

GLP compliance:

no

Test substance thermally stable:

yes

Operating temp.:

380 °C

Transformation products:

no

Test substance stable to sunlight:

not determined

Test substance stable to metals / metal ions:

not determined

RESULTS:

- Self-heating:

Beginning at about 154 °C the sample showed an exothermic reaction (v_max: 183 °C). The wire mesh basket was empty after the measurement.

- Self-reactive:

At a heating rate of 3 K/min, an exothermic reaction started at 168 °C with a total heat release of about 10 kJ/kg, which was interfered by an endothermic effect. It was followed by a second exothermic reaction starting at 285 °C with a heat release of about 135 kJ/kg. The repeat measurement under argon delivered a comparable curve. The first exothermic reaction was an oxidizing reaction with the residual oxygen in the glass container. It disappears under argon. Based on this thermal behavior it is expected that SADT is > 75 °C.

Conclusions:

3-Methoxy-18-methyl-2,5(10)-estradien-17-one is classified as a not self-heating substance when tested according to UN-MTC Procedure N.4 and in the sense of CLP Annex I, 2.11. Also it can be concluded by expert judgement that the substance is not selfreactive in the sense of CLP 2.8.

Executive summary:

The tests were performed as stipulated in UN-MTC test procedure (Part III, sub-section 33.2.1.4.1, Test N.4 `Test method for self-heating substances) and according to UN-MTC Procedure H.4 (SADT). The sample in its delivered state was filled in a sample container. The container was housed in the cover and hung at the centre of the oven. The oven temperature was raised to the starting temperature and kept there for at least 24 hours. The temperature of the sample and of the oven was recorded continuously. 3-Methoxy-18-methyl-2,5(10)-estradien-17-on is classified as a not self-heating substance when tested according to UN-MTC Procedure N.4 and in the sense of CLP Annex I, 2.11. Also it can be concluded by expert judgement that 3-Methoxy-18-methyl-2,5(10)-estradien-17-on is not selfreactive in the sense of CLP 2.8. The determination according to UN-MTC Procedure H.4 (SADT) is not necessary.

Description of key information

3-Methoxy-18-methyl-2,5(10)-estradien-17-on is stable since it shows no self-reactive or self-heating properties, there are no exothermic reactions up to 140 °C and since the test substance is a solid, the criteria of metal corrosion does not apply.

Justification for classification or non-classification

3-Methoxy-18-methyl-2,5(10)-estradien-17-on does not need to be classified since it is stable and shows no corrosive properties.