Registration Dossier
Registration Dossier
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EC number: 405-370-0 | CAS number: 6334-25-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported2
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study already evaluated and accepted by national autorities. Information from migrated NONS file as per inquiry # [06-0000014662-72-00000].
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 405-370-0
- EC Name:
- -
- Cas Number:
- 6334-25-4
- Molecular formula:
- C14H28N2O6
- IUPAC Name:
- N,N,N',N',-tetrakis(2-hydroxyethyl)hexanediamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: Substance gound and moistened with 0.85% saline
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- ca. 0
- Remarks on result:
- other: Max. duration: d; Max value at end of observation period:
- Irritation parameter:
- edema score
- Basis:
- mean
- Score:
- ca. 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period:
- Other effects:
- Erythema (grade 1) was recorded in 2 animals at 1 hour but was no longer evident at 24h
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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