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EC number: 206-525-3 | CAS number: 352-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-08-29 to 1995-06-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 4 April 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted 29 December 1984
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 9.5, 13.3, 18.6, 26, 36.4, 51, 71.4, 100% saturated solution
- Sampling method: samples were analysed in triplicates at 0 and 48 h
- Sample storage conditions before analysis: no data - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 5 g/L (preliminary test) and 0.1 g/L (definitive test) of the test item are stirred for 5 h at 30°C and 1 d at 20°C. Unsolubilised test item is separated by means of centrifugation.
- preliminary test: A concentration range between 100 % and 0.1% was prepared from the saturated stock solution.
- definitive test: Concentrations prepared from saturated stock solution: 100% (64.1 mg/L); 71.4% (40.7 mg/L); 51% (30.1 mg/L); 36.4% (19 mg/L); 26% (15.2 mg/L); 18.6% (9.2 mg/L); 13.3% (7.7 mg/L); 9.5% (7.8 mg/L); 6.8% ( - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: Daphnia magna Straus
- Source: laboratory's own culture
- Age at study initiation: <24 h
- Feeding during test: no data
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): no data - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
- Test temperature:
- 18-20°C
- pH:
- - highest initial pH: 7.50
- final pH range: 7.63 - 8.27 - Dissolved oxygen:
- - final range of oxygen content: 7.4 - 8.1 mg/L
- Nominal and measured concentrations:
- nominal [% of saturated solution]: 100, 71.4, 51, 36.4, 26, 18.6, 13.3, 9.5, 6.8
measured, initial [mg/L]: 64.1, 40.7, 30.1, 19, 15.2, 9.2, 7.7, 7.8, (measured, final [mg/L]: 59, 38.3, 26.1, 16.6, 12.8, 6.45, ( - Details on test conditions:
- TEST SYSTEM
- Test vessel: penicllin-type bottles
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: nominal capacity of 120 mL with teflon septa
- Aeration: aeration of solutions until oxygen saturation
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water (OECD202), Elendt M7
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : immobilisation (24 and 48 h)
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.4
- Range finding study
- Test concentrations: 0.01 - 100% of saturated solution
- Results used to determine the conditions for the definitive study: results not given in the study report- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (results from 1995-05-10)
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 48 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 35 - 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% CL: 16 - 24 mg/L
- Details on results:
- - Other biological observations: none reported
- Mortality of control: 0%- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- 24 h EC50: 1.2 mg/L for potassium dichromate (measured 1995-05-10)- Reported statistics and error estimates:
- - Final concentrations were found to be within 80% of the initial concentrations with the exception of 18.6%, which was found to be 70% of the initial concentration. However, this result was not considered signifcantly different from the average value of the initial concentration and was therefore included in the interval of confidence.
Initial measured concentration [mg/L]
Number of living Daphnids after 24 h
% immobilised after 24 h
Number of living Daphnids after 48 h
% immobilised after 48 h
0
20
0
20
0
<0.8
19
5
18
10
7.8
19
5
18
10
7.7
19
5
19
5
9.2
19
5
16
20
15.2
19
5
14
30
19
17
15
9
55
30.1
13
35
8
60
40.7
10
50
3
85
64.1
9
55
0
100
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24 h EC50 of TFMEA in Daphnia magna was 48 mg/L (95% CL = 35 - 100 mg/L). The 48 h EC50 was 19 mg/L (95% CL = 16 - 24 mg/L).
- Executive summary:
The acute toxicity of TFMEA to Daphnia magna was studied under static conditions according to OECD Guideline 202, adopted 4 April 2008, and EU test method C.2, 29 December 1992. Daphnids were exposed to control, and test chemical at initial concentrations of <0.8, 7.8, 7.7, 9.2, 15.2, 19, 30.1, 40.7, 64.1 mg/L. The 24 h EC50 based on immobilisation was 48 mg/L (95% CL = 35 - 100 mg/L). The 48 h EC50 based on immobilization was 19 mg/L (95% CL = 16 - 24 mg/L).
Results synopsis:
Test Organism Age (e.g. 1stinstar): Daphnia magna Straus, <24 hours old
Test Type: Static
24 h EC50: 48 mg/L (95% CL = 35 - 100 mg/L)
48 h EC50: 19 mg/L (95% CL = 16 - 24 mg/L)
Endpoint(s) Effected: mobility
Reference
Description of key information
48 h EC50=19 mg/L (95% CL = 16 - 24 mg/L); OECD guideline 202/EU method C.2, static
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 19 mg/L
Additional information
One reliable (RL=2), relevant and adequate study on the acute toxicity of TFMEA to aquatic invertebrates is available:
The acute toxicity of TFMEA to Daphnia magna was studied under static conditions according to OECD Guideline 202, adopted 4 April 2008, and EU test method C.2, 29 December 1992. Daphnids were exposed to control, and test chemical at initial concentrations of <0.8, 7.8, 7.7, 9.2, 15.2, 19, 30.1, 40.7, 64.1 mg/L. The 48 h EC50 based on immobilisation was 19 mg/L (95% CL = 16 - 24 mg/L).
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