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EC number: 207-300-2 | CAS number: 460-00-4
Endpoint summary
Administrative data
Description of key information
Appearance:
Based on data available from authoriative database Gestis,2016,the chemical1-Bromo-4-fluorobenzeneis colorless liquid in appearance with aromatic odour.
Freezing Point:
Based on available data from reliable sources such as authoritative database and review literature, the freezing point of chemical 1-Bromo-4-fluorobenzene was determined to be -16 °C.
Boiling point:
The boiling point determination of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the test guideline OECD 103. The method followed was according to Siwoloboff. The boiling point of 1-bromo-4-fluorobenzene is 149.3°C at 973.5 hPa.
Density:
The density of test item 1-bromo-4- fluorobenzene (CAS No. 460-00 -4) was determined following OECD Guideline 109 and according to the IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision) using glass pyknometer. The mean density of test item was determine to be 1.6026 g/cm³ at 20°C and 973.1hPa.
Particle Size Distribution:
In accordance with REACH Chapter R.7A Endpoint Specific Guidance, specifically R.7.1.14.1 Information requirements on granulometry, the granulometry study does not need to be conducted as the test substance, 1-bromo-4-fluorobenzene is marketed or used in a nonsolid or granular form. The test substance, 1-bromo-4-fluorobenzene is a colorless liquid at room temperature and as such this study is not technically feasible. Hence this endpoint was considered for waiver.
Vapour Pressure:
Data from authoritative databases, modelling databases and handbooks indicates that the estimated vapor pressure of the test chemical lies in the range of 370 - 430 Pa at 25 deg C.
The estimated vapour pressure used for chemical safety assessment of 1 -bromo-4 -fluorobenzene was 499 Pa at 25 deg C, which lies in the above range.
Partition coefficient:
The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 1.5 to 4.2.The Log Pow value was determined to be 3.018 ± 0.001at 25°C. By considering this log Kow value test chemical is considered to be hydrophilic in nature.
Water solubility:
The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C. Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.
Solubility in organic solvents:
Solubility of the test chemical in various organic solvents was determined experimentally. 1 -bromo-4 -fluorobenzene was determined to be soluble in ethanol, ether and chloroform.
Surface tension:
From the available data from predicted chemspider database, the surface tension was predicted to be 33.8±3.0 dyne/cm.
Flash point:
The flash point determination of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done following closed cup method using Abel's flash point apparatus. The mean flash point of 1-bromo-4-fluorobenzene was determine to be 56.6°C at 973.6 hPa.
Autoflammability:
The auto ignition temperature for 1-bromo-4-fluorobenzene is reported as > 350°C. This indicates that 1-bromo-4-fluorobenzene is not auto-flammable.
Flammability:
The substance has a flash point of 56°C, thereby classifying it as a flammable liquid. Since the substance is already classified as flammable, a separate flammability test was not conducted and hende the endpoint is considered for waiver.
Explosiveness:
In accordance with column 2 of Annex VII of the REACH regulation, the study does not need to be conducted since there are no chemical groups associated with explosive properties present in the molecule of 1-Bromo-4-fluorobenzene. Thus, the chemical is likely to be "Non explosive". Hence this end point was considered for waiver.
Oxidising Properities:
In accordance with column 2 of REACH annex VII the substances that fall into any of the flammable classifications should not be tested for oxidising potential. Since the test chemical, 1-bromo-4-fluorobenzene has a flash point <than 60 degree C,and was classified under Flammable Liquid Category 3.
Therefore this property is considered for waiver.
pH:
The pH determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the test guideline OECD 122. The mean pH of the test dispersion was determined with the help of digital pH meter. The mean pH was determine to be 7.83 at 30 °C.
Viscosity:
The viscosity determination of test substance was done as per the test guideline OECD 114 using Redwood Viscometer No. 1. Kinematic viscosity (experimental) of 1-bromo-4-fluorobenzene ( CAS No. 460-00-4) at 20°C and 40°C is 13.2792mm²/sec and 11.0880mm²/s, respectively. Dynamic viscosity (calculated) of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) at 20°C and 40°C is 21.2812mPa.S and 17.7696 mPa.S, respectively.
Additional information
Appearance:
Based on data available from authoritative database Gestis, 2016, the chemical 1-Bromo-4-fluorobenzene was colorless liquid in appearance with aromatic odor.
Other supporting studies from reliable sources such as authoritative database and review handbooks also suggests that chemical is colorless liquid in appearance.
Freezing Point:
Based on available data from reliable sources such as authoritative database and review literature, the freezing point of chemical 1-Bromo-4-fluorobenzene was determined to be -16 °C.
Other supporting studies from authoritative sources also indicate that the freezing point of chemical 1-Bromo-4-fluorobenzene was between the range of -17.4 degree C to -7.77 °C, and the selected key study value -16 degree C lies between the ranges as mentioned above.
Boiling point:
The boiling point determination of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the test guideline OECD 103. The method followed was according to Siwoloboff. The boiling point of 1-bromo-4-fluorobenzene is 149.3°C at 973.5 hPa.
Based on available data from reliable sources such as review literature, the boiling point of chemical 1-Bromo-4-fluorobenzene was determined to be in the range of 152-155 degree C at 760 mmHg pressure.
Other supporting studies from authoritative databases and handbooks also suggests that the boiling point of chemical
1-Bromo-4-fluorobenzene was determined to be in the range of 150 -152 °C.
On the basis of above key experimental study the boiling point of 1-bromo-4-fluorobenzene is 149.3°C at 973.5 hPa.
Density:
The density of test item 1-bromo-4- fluorobenzene (CAS No. 460-00 -4) was determined following OECD Guideline 109 and according to the IS 4730 : 1994 (Reaffirmed 2010) – Method for Determination of Density of Liquids (First Revision) using glass pyknometer. The mean density of test item was determine to be 1.6026 g/cm³ at 20°C and 973.1hPa.
Based on available data from reliable source such as authoritative database, IFA -Gestis, 2016 the density of chemical 1-Bromo-4-fluorobenzene was determined to be 1.593 g/cm³ at 25 deg C.
Other supporting studies from reliable sources such as review handbooks and authoritative database also suggests that the density of chemical 1-Bromo-4-fluorobenzene was in the range of 1.4696 -1.593 g/cm3.
Thus based on the key study the mean density of test item was determine to be 1.6026 g/cm³ at 20°C and 973.1hPa.
Particle Size Distribution:
In accordance with REACH Chapter R.7A Endpoint Specific Guidance, specifically R.7.1.14.1 Information requirements on granulometry, the granulometry study does not need to be conducted as the test substance, 1-bromo-4-fluorobenzene is marketed or used in a nonsolid or granular form. The test substance, 1-bromo-4-fluorobenzene is a colorless liquid at room temperature and as such this study is not technically feasible. Hence this endpoint was considered for waiver.
Vapour Pressure:
Data from authoritative databases, modelling databases and handbooks indicates that the estimated vapor pressure of the test chemical lies in the range of 370 - 430 Pa at 25 deg C.
The estimated vapour pressure used for chemical safety assessment of 1 -bromo-4 -fluorobenzene was 499 Pa at 25 deg C, which lies in the above range.
Partition coefficient:
The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 1.5 to 4.2.The Log Pow value was determined to be 3.018 ± 0.001at 25°C. By considering this log Kow value test chemical is considered to be hydrophilic in nature.
Information from various authoritative databases, handbooks and peer reviewed articles suggests that the octanol water partition coefficient of the test chemical lies in the range of 2.9 - 3.4. The octanol water partition coefficient used for the chemical safety assessment of 1 -bromo-4 -fluorobenzene is 3.08, which falls in the above the range.
By considering this log Kow value test chemical is considered to be hydrophilic in nature.
Water solubility:
The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C. Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.
Data from various authoritative databases and handbooks suggests that the estimated water solubility of 1 -bromo-4 -fluorobenzene at 25 deg C was 136.4 mg/l. This value indicates that the test chemical is moderately soluble in water.
Thus on the basis of above data, chemical consider to be moderately soluble in water.
Solubility in organic solvents:
Solubility of the test chemical in various organic solvents was determined experimentally. 1 -bromo-4 -fluorobenzene was determined to be soluble in ethanol, ether and chloroform.
Surface tension:
From the available data from predicted chemspider database, the surface tension was predicted to be 33.8±3.0 dyne/cm.
Flash point:
The flash point determination of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done following closed cup method using Abel's flash point apparatus. The mean flash point of 1-bromo-4-fluorobenzene was determine to be 56.6°C at 973.6 hPa.
From other reliable sources & authoritative databases flash point of test chemical is determine in range from 53 degree C to 60 degree C.
Also based on criteria mentioned in CLP regulation the chemical has flash point <than 60 degree C, thus the 1-Bromo-4-fluorobenzene (460-00-4) was classified in Flammable Liquid Category 3.
Autoflammability:
The auto ignition temperature for 1-bromo-4-fluorobenzene is reported as > 350°C. This indicates that 1-bromo-4-fluorobenzene is not auto-flammable.
Flammability:
The substance has a flash point of 56°C, thereby classifying it as a flammable liquid. Since the substance is already classified as flammable, a separate flammability test was not conducted and hende the endpoint is considered for waiver.
Explosiveness:
In accordance with column 2 of Annex VII of the REACH regulation, the study does not need to be conducted since there are no chemical groups associated with explosive properties present in the molecule of 1-Bromo-4-fluorobenzene. Thus, the chemical is likely to be "Non explosive". Hence this end point was considered for waiver.
Oxidising Properities:
In accordance with column 2 of REACH annex VII the substances that fall into any of the flammable classifications should not be tested for oxidising potential. Since the test chemical, 1-bromo-4-fluorobenzene has a flash point <than 60 degree C,and was classified under Flammable Liquid Category 3.
Therefore this property is considered for waiver.
pH:
The pH determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the test guideline OECD 122. The mean pH of the test dispersion was determined with the help of digital pH meter. The mean pH was determine to be 7.83 at 30 °C.
Viscosity:
The viscosity determination of test substance was done as per the test guideline OECD 114 using Redwood Viscometer No. 1. Kinematic viscosity (experimental) of 1-bromo-4-fluorobenzene ( CAS No. 460-00-4) at 20°C and 40°C is 13.2792mm²/sec and 11.0880mm²/s, respectively. Dynamic viscosity (calculated) of 1-bromo-4-fluorobenzene (CAS No. 460-00-4) at 20°C and 40°C is 21.2812mPa.S and 17.7696 mPa.S, respectively.
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