Registration Dossier
Registration Dossier
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EC number: 700-151-9 | CAS number: 1101874-33-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The In Vitro Genetic Toxicity of CASRN 1101874-33-2 was evaluated in a Bacterial Reverse Mutation Assay and a Mouse Lymphoma Assay. The Bacterial Reverse Mutation Assay was GLP-compliant and performed according to OECD Guideline 471 (1998) using S. typhimurium strains TA98, TA100, TA1535 and TA 1537 and E. coli strain WP2 uvrA in the presence and absence of metabolic activation. No increase in frequency of revertant colonies was observed in any tester strain following treatment with the material in either the presence or absence of metabolic activation. The Mouse Lymphoma Assay was GLP-compliant and performed according to OECD Guideline 476 (1998) using mouse lymphoma L5178Y TK+/- cells. In this assay, no concentration-related increase in mutant frequency or change in colony size distribution was observed following treatment with the material in either the presence or absence of metabolic activation. Based on the results of the in vitro genetic toxicity assays, the material has low potential for genetic toxicity.
Endpoint Conclusion:
Justification for classification or non-classification
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