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Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400123, a complex mixture of components. Low to moderate absorption and systemic availability of WS400123 or some of its components after oral exposure has been concluded from small, non-adverse changes observed in some blood parameters in the subacute and subchronic toxicity studies in rats. Dermal absorption has been concluded from the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400123.

Exposure of humans to WS400123 by the inhalation route is unlikely, because of its very low vapour pressure (1 x 10-3Pa at 25°C), its decomposition at high temperature without boiling (above ca. 150°C) and because it is a highly viscous liquid.

All available study results gave no indication regarding the metabolic pathway, distribution or excretion of WS400123.

Bioaccumulation was not investigated, but in view of its Log10Pow< +1, WS400123 is not considered to have a bioaccumulation potential.