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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
< 1
Temp.:
25 °C
pH:
4
Key result
Type:
log Pow
Partition coefficient:
< 1
Temp.:
25 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
< 1
Temp.:
25 °C
pH:
9
Details on results:
At each pH value, the great majority of the components of the test material were found to have retention times less than that of the lowest reference standard, acetanilide, indicating log10Pow values of less than 1.0.

Description of key information

Log Pow = < 1.0 at pH 4, 7 and 9 at 25°C (OECD 117, EU A8)

Key value for chemical safety assessment

Additional information

Log Kow (Log Pow) < 1.0 at the temperature of 25°C