Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data, List III
Author:
Smyth H.F., Carpetnter C.P. and Weil C. S.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol., 31, 60-62

Materials and methods

Principles of method if other than guideline:
Concentrated vapor inhalation was performed exposing groups of 6 male or female albino rats to a flowing stream of vapor-loaded air. The vapor-air mixture was generated by passing 2.5 l/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 ml of the test substance in a gaswashing bottle. Inhalations were continued for 8 hours in a logarithmic series. The observation period lasted 14 days.
GLP compliance:
no
Test type:
other: inhalation risk test
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: 2.5 l/min
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
4000 ppm (19613,27 mg/m³)
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Exp. duration:
4 h
Remarks on result:
other: 2/6 animals died at 4000 ppm (19613,27 mg/m³)
Mortality:
2/6 animals died during 14 days.
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion