Registration Dossier
Registration Dossier
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EC number: 807-448-3 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 February 2014 - 17 March 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- Column temperature: 40°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies 1100 HPLC system
- Column: Waters XSelect HSS Cyano 5 µm (150x4.6 mm id)
- Detection system: Agilent variable wavelength detector (VWD) and Polymer Laboratories evaporative light scattering detector 2100 (ELSD)
- VWD wavelength: 210 nm
MOBILE PHASES
- Type: methanol: water (55:45 v/v)
- Flow rate: 1.0 mL/min
- Experiments with additives carried out on separate columns: no
- pH: 7
- Solutes for dissolving test and reference substances: Test item - 0.2507g diluted to 50 mL with THF
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (formamide at 670 mg/L in mobile phase)
REFERENCE SUBSTANCES
- Identity: see table below
DETERMINATION OF RETENTION TIMES
- Injection volume: 10 µL
REPETITIONS
- Number of determinations: 2 - Type:
- log Koc
- Value:
- > 5.63
- Temp.:
- 40 °C
- Remarks on result:
- other: Column temperature: 40°C
- Type:
- Koc
- Value:
- > 427 000
- Temp.:
- 40 °C
- Remarks on result:
- other: Column temperature: 40°C
- Details on results (HPLC method):
- Please see attachments
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test material was assessed in accordance with OECD Guideline 121. The adsorption coefficient (Koc) of the test item has been determined to be > 4.27E+05, LogKoc > 5.63.
- Executive summary:
Introduction
The adsorption coefficient of the test item was determined using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Method
The test utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
Results
The adsorption coefficient (Koc) of the test item has been determined to be > 4.27E+05, LogKoc > 5.63.
Reference
Please see attachments
Description of key information
The adsorption coefficient of the test material was assessed in accordance with OECD Guideline 121. The adsorption coefficient (Koc) of the test item has been determined to be > 4.27E+05, LogKoc > 5.63.
Key value for chemical safety assessment
- Koc at 20 °C:
- 427 000
Additional information
The adsorption coefficient of the test item was determined using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001. The test utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The adsorption coefficient (Koc) of the test item has been determined to be > 4.27E+05, LogKoc > 5.63.
[LogKoc: 5.63]
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