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EC number: 209-939-2 | CAS number: 598-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From April 14, 1986 to April 16, 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to method given by U. S. Environmental Protection Agency (1975) and American Public Health Association (1980), in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: U. S. Environmental Protection Agency (1975). Methods of acute toxicity tests with fish, macroinvertebrates and amphibians
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: American Public Health Association (1980). Standard methods for examination of water and wastewater
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl carbamate
- EC Number:
- 209-939-2
- EC Name:
- Methyl carbamate
- Cas Number:
- 598-55-0
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- methyl carbamate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain: Daphnia magna
- Source: ABC facilities
- Food type: The adult Daphnia were fed algae (Selenastrum capricornutum) at least every 3 d prior to testing and supplemented with a suspension of fish food.
ACCLIMATIZATION
- Acclimatization period: 3 d
Study design
- Test type:
- static
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 225-275 ppm
- Test temperature:
- 20°C
- pH:
- 8.4
- Dissolved oxygen:
- 7.0 - 9.2 mg/L
- Nominal and measured concentrations:
- 0, 100, 180, 320, 560 and 1,000 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250-mL glass beakers containing 200 mL of ABC aged well water.
- No. of organisms per vessel: 10 per beaker
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Alkalinity: 325-375 ppm
- Conductivity: 700 μmhos/cm
- Aluminum: <20 ppb
- Arsenic: <0.2 ppb
- Cadmium: <2 ppb
- Chromium: <3 ppb
- Cobalt: <4 ppb
- Copper: <3 ppb
- Iron: 12 ppb
- Lead: <5 ppb
-Mercury: <0.5 ppb
- Nickel: <15 ppb
- Silver: <5 ppb
- Zinc: 11 ppb
- Measured organophosphorus pesticides: Less than minimum detectable limit (<0.10 ppb)
- Measured organochlorine pesticides plus PCB's: Less than minimum detectable limit (<0.50 ppb)
- Intervals of water quality measurement: 0 and 48 h
OTHER TEST CONDITIONS
- Photoperiod: 16 h daylight photoperiod, with 30 min simulated dawn and dusk periods
- Light intensity: 50-70 foot candles
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Mortality and behavioral observations at 24 h and 48 h.
TEST CONCENTRATIONS
- Range finding study: 10 Daphnia each in exposure concentrations of 1.0, 10 and 100 mg/L. From this information, concentration were selected for the definitive bioassay
- Test concentrations for definitive study: 0, 100, 180, 320, 560 and 1,000 mg/L
- Spacing factor for concentration: Geometric series in which the ratio between consecutive concentrations is between 1.5 and 2.0.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Lack of mortality and abnormal effects
- Details on results:
- No abnormal effects such as mortality, surfacing or Daphnids lying on the bottom of test vessels were observed in any of the test concentrations during the test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 24 h and 48 h LC50 for the test substance was determined to be >1,000 mg/L and NOEC was determined to be 1,000 mg/L.
- Executive summary:
A study was conducted to determine the acute toxicity of the test substance to Daphnia magna under static conditions, according to method given by U. S. Environmental Protection Agency (1975) and American Public Health Association (1980), in compliance with GLP. Based on the findings of a range finding test, ten Daphnia (less than 24 h old) per beaker were exposed to test substance concentration of 0, 100, 180, 320, 560 and 1,000 mg/L in duplicate for 48 h. Water quality parameters of temperature, dissolved oxygen and pH were measured at 0 and 48 h interval and they were found to be within acceptable limits. No abnormal effects such as mortality, surfacing or Daphnids lying on the bottom of test vessels were observed in any of the test concentrations during the test. Hence based on the findings of the study, the 24 h and 48 h LC50 for the test substance was determined to be >1,000 mg/L and NOEC was determined to be 1,000 mg/L (Forbis AD, 1986).
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