Registration Dossier
Registration Dossier
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EC number: 700-404-3 | CAS number: 127929-37-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 2,2-bis({[3-(4-ethylpiperazin-1-yl)propanoyl]oxy}methyl)butyl 3-(4-ethylpiperazin-1-yl)propanoate
- EC Number:
- 700-404-3
- Cas Number:
- 127929-37-7
- Molecular formula:
- C33H62N6O6
- IUPAC Name:
- 2,2-bis({[3-(4-ethylpiperazin-1-yl)propanoyl]oxy}methyl)butyl 3-(4-ethylpiperazin-1-yl)propanoate
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- >= 157 - <= 169 kg/m³
- Temp.:
- 20.1 °C
- pH:
- 7.87
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
- Executive summary:
In a preliminary study, the solubility of the test item in water was estimated as 10 - 50 g/l.
In the main study, approx. 12.5 g were weighed into each of six individual vessels, 50 ml water was added, and the vessels were shaken at room temperature.
On days 1 and 2, vessel 1 was taken from the shaking apparatus and stored at 20 +-0.1°C for equilibration. Samples were taken, filtrated and diluted in order to reach the calibrated range. Then they were analysed using photometric absorption at 190 nm as shaking of the test vessels was continued.
No differences above 15% in the concentration of the solution could be determined between the sampling dates 1, 2 and 3, supporting the hypothesis, that the maximum concentration of the test item had been reached. Therefore, on day 3, vessels 2 - 6 were sampled and analysed in the same fashion.
At the plateau, the concentration of B 1061 in water had reached
163 +- 6 g/l (=kg/m³ in SI units) at 20 +-0.5 °C
(mean value +- standard deviation of five individual vessels).
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